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Uncovering the individual immunotherapeutic roles of PTPN1 and PTPN2 in T cells during dual inhibition
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DOI：10.1016/j.isci.2025.113610.png)
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Abstract
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• Dual, but not single, PTPN1 and PTPN2 loss enhances T cell cytotoxicity • The IL-10/STAT3 signaling emerges as a key driver of enhanced T cell function • Dual inhibition synergizes with PD-1 blockade to improve tumor control in vivo
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