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Universal catalytic endothelial lineage nanovesicles for targeting and rescuing ischemic endothelium

delete2026-08-05
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OA
AI
H
Hongyi Jiang
Y
Yumeng Wang
H
Haosheng Huang
L
Liang Zhu
H
Hanting Shen
L
Liting Jiang
C
Chihao Lin
H
Huangyi Fang
G
Gang Zheng
J
Junfeng Shi
X
Xinghe Xue
J
Jilong Wang
J
Jian Lin *
J
Junjie Deng *
L
Liang Chen *
X
Xiaoyun Pan *
DOI：10.1016/j.xcrm.2026.102972delete
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Abstract

Abstract

En 中文
• iPSC-derived endothelial lineage nanovesicles carry pro-angiogenic cargo • Nanozyme arming enables catalytic ROS scavenging in ischemic endothelium • CXCR4/SDF-1 homing and endothelial affinity drive dual targeting • CeO2-NMUiECs provide a universal strategy to treat diverse ischemic diseases
Keywords:
ischemic diseases
endothelial dysfunction
biomimetic nanovesicles
ceria nanozymes
dual-targeting

Journal

Cell Reports Medicine cover
Cell Reports Medicine
IF:
10.6
Papers:
2.2K
Citations:
8.9K

Organization

U
University of Chinese Academy of Sciences
Scholars:
5.7K
Papers: 2.3K
Citations: 24.6W
H
hunan university
Scholars:
4.3W
Papers: 3.2W
Citations: 70
W
wenzhou medical university
Scholars:
6.2K
Papers: 1.6K
Citations: 0
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