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Unlocking Interstitial Fluid for Acute Coronary Syndrome Diagnosis: Ultrasensitive Troponin I Detection Using Imprinted Polymer Nanoparticles
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DOI：10.1039/D5NH00441A.png)
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Abstract
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This study presents the first detection of cardiac troponin I (cTnI); a vital biomarker for acute coronary syndrome diagnosis (ACS); in human interstitial fluid (ISF); which was collected using electroporation. Measurements were performed using molecularly imprinted polymer nanoparticles as synthetic recognition elements and a heat-transfer method within a microfluidic system; yielding results within 15-20 min. This approach demonstrated reliable cTnI quantification across a wide; physiologically relevant concentration range of 0.1 to 1000 pg mL - 1 in spiked ISF; achieving an excellent detection limit of 0.41 ± 0.06 pg mL -1 . Comparisons with conventional patient sample fluids were conducted by repeating experiments with cTnI-spiked plasma and serum; which exhibited similar detection limits of 0.45 ± 0.01 and 0.49 ± 0.04 pg mL -1 ; respectively. The developed sensor offers a rapid; highly sensitive; non-invasive; and costeffective platform for point-of-care ACS diagnosis in ISF; potentially improving patient outcomes and easing healthcare burdens.
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