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Unraveling the mechanisms of Tou-Tong-Xin-1-Hao granules in treating migraine: A multi-modal study integrating microbiome, metabolomics, and network pharmacology, and experimental validation
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DOI：10.1016/j.microc.2026.119316.png)
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Abstract
En 中文
• XYH granules alleviate migraine-like behaviors in rats. • XYH modulates gut microbiota and cerebral metabolism. • Results suggest a “gut–brain–energy metabolism” axis. • Network pharmacology supports multi-target mechanisms of XYH. • Metabolomics identifies succinic acid alteration as a metabolic feature associated with XYH intervention.
Keywords:
Migraine
Metabolomics
Network pharmacology
Tou Tong Xin 1 Hao
Energy metabolism
Neuroinflammation
Journal
IF:
5.1
Papers:
1.8W
Citations:
3.7W
Organization
Cited Papers