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Unraveling the potential and challenges of photosynthetic microalgae for oxygenating engineered tissues
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DOI：10.1016/j.bioadv.2026.214911.png)
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Abstract
En 中文
• Photosynthetic microalgae enable transient oxygenation in di4usion-limited 3D constructs. • Direct microalgae-animal cell co-culture improves early cell viability under hypoxic conditions. • Photosynthetic activity rapidly declines under standard animal cell culture conditions. • An intermediate cell-to-microalgae ratio (1:5) provides the most consistent transient benefit. • Co-culture outcomes are strongly a4ected by microalgal physiological variability and culture conditions.
Keywords:
Photosynthetic microalgae
Tissue engineering
Oxygen-generating biomaterials
Living materials
Microalgae-animal cell co-culture
Chlorella vulgaris
Photosynthetic oxygenation
Three-dimensional hydrogels
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