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Unveiling Misdiagnosis: Rethinking Seronegative NMOSD

delete2025-08-16
delete0
PRE
AI
M
Mary V. Lang
G
Grant M. Welk
D
Deena Tajfirouz
K
Kevin D. Chodnicki
S
Sean J. Pittock
E
Eoin P. Flanagan
J
John J. Chen
DOI：10.1177/13524585251360648delete
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Abstract

Abstract

En 中文
<jats:p>Seronegative neuromyelitis optica spectrum disorder (NMOSD) is a diagnostic challenge. This study aimed to characterize misapplication of the 2015 international criteria for seronegative NMOSD. We reviewed 35 consecutive seronegative NMOSD referrals to a tertiary center. Two (6%) met formal criteria, and 2 (6%) were clinically suspected of NMOSD without fulfilling radiologic supportive criteria. Alternative diagnoses were common including multiple sclerosis (37%), optic neuritis (14%), functional neurologic disorder (11%), and other (38%). Immunosuppression with rituximab was used in 3 of 4 patients with functional neurologic disorder. Misapplication of the 2015 criteria is common, and alternative explanations in seronegative NMOSD patients should be strongly considered.</jats:p>
Keywords:
seronegative NMOSD
diagnostic challenge
2015 international criteria
alternative diagnoses
rituximab

Journal

Multiple Sclerosis Journal cover
Multiple Sclerosis Journal
IF:
5
Papers:
5.4K
Citations:
1.4W

Organization

No organization information available