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Unwrapping the phytofabrication of bimetallic silver-selenium nanoparticles: Antibacterial, Anti-virulence (Targeting magA and toxA genes), anti-diabetic, antioxidant, anti-ovarian, and anti-prostate cancer activities
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DOI：10.1515/gps-2025-0087.png)
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Abstract
En 中文
The current study successfully biosynthesized bimetallic silver-selenium nanoparticles (Ag-Se NPs) using an extract from Salvia hispanica seeds. Our research revealed that Salvia hispanica seed extract is a substantial source of various phytochemicals. Ag-Se NPs were characterized by UV, XRD, FTIR, HR-TEM, SEM-EDX analyses, and mapping studies. Moreover, Ag-Se NPs showed antimicrobial activity against E. coli, K. pneumoniae, P. aeruginosa, S. aureus, and B. subtilis. In addition, Ag-Se NPs demonstrated antibiofilm effectiveness against two biofilm-forming bacteria, K. pneumoniae and S. aureus. Ag-Se NPs exhibited significant antioxidant activity in the DPPH and ABTS experiments, surpassing ascorbic acid (IC50 = 354 and 241 mu gmL-1). In contrast, the reported low IC50 values for the tested Ag-Se NPs against prostate (PC3), and ovarian (SK-OV3) cancerous cell lines were 52.5 and 62.94 mu gmL-1, respectively, indicating their significant efficacy against these cancerous cell lines, and the IC50 for the Vero cells was 187.8 mu gmL-1. Anti-diabetic effects were demonstrated by the inhibition of alpha-amylase (91.1%) and alpha-glucosidase (85.6%) at 1 mgmL-1. Ultimately, Ag-Se NP dosage at the MIC values exhibited reduced expression of the virulence genes magA and toxA in K. pneumoniae and P. aeruginosa by 29.4% and 24.5%, respectively.
Keywords:
Ag-Se NPs
characterization
phytochemical
antibacterial
anticancer and antioxidants
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