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Update on treatment of abdominal pain in irritable bowel syndrome: A narrative review
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DOI：10.1016/j.pharmthera.2023.108400.png)
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Abstract
En 中文
The objectives of this narrative review are to update readers on the current state-of-the-art regarding diverse approaches for the treatment of pain, global symptoms, or adequate relief in irritable bowel syndrome (IBS). The article appraises medications, dietary interventions including low fermentable oligosaccharides, disaccha-rides, and monosaccharides and polyols (FODMAP) diet, fecal microbial transplantation (FMT), electrical approaches, and behavioral therapies including cognitive behavioral therapy (CBT), gut-directed hypnotherapy (GDH), mindfulness, and open-label placebo. Current evidence demonstrates only modest benefit in global IBS symptoms and pain relief. A future approach that identifies pathophysiological mechanisms of IBS through vali-dated biomarkers has the potential to individualize treatment of patients rather than sequential therapeutic trial and error approaches. (c) 2023 Elsevier Inc. All rights reserved.
Keywords:
Pharmacological
Behavioral
Electrical
Neuromodulators
Pain
Diet
Microbiome