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Update Raynaud Phenomenon

delete2026-02-01
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L Caspary *
DOI：10.1055/a-2769-8750delete
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Abstract

Abstract

En 中文
Socioeconomic impact Among the general population in northern Sweden, the prevalence of Raynaud's phenomenon (RP) was 12%; this did not affect the duration and frequency of illness or livelihood among workers employed in colder environments. Patients with RP in the context of systemic sclerosis (SSc) had a 25% impairment in the usability of their hands, with a tendency to worsen, but often due to tendon damage. Influencing factors Patients with a lower body mass index (BMI) are more frequently affected by RP. It also occurs more often when patients lose weight, including as a result of dieting. RP also occurs frequently at low outdoor temperatures. This correlation does not only apply to primary RP - a clear connection can also be demonstrated in cases of underlying SSc. Causes Anxiety disorders and depression are more common in people with RP than in the general population - and conversely, they can apparently contribute to the development of RP. RP also occurs more frequently in cases of peripheral sensory polyneuropathy. Several medications can be added to the list of causes of RP, including silicone from breast implants. Diagnosis Newly occurring RP may be an early form of SSc (VEDOSS). Nailfold capillary microscopy is an important component in the diagnosis of SSc. However, capillary changes alone are not sufficient to make this diagnosis. If no other symptoms of the disease are present, primary RP can be assumed after 5-10 years. Treatment Therapy In primary RP, cold prophylactic measures are the main focus. Heated gloves help to reduce RP. The use of silver threads does not appear to offer any additional benefits. New guidelines for the pharmacological treatment of SSc have been published by the EULAR (European Alliance of Associations for Rheumatology) and the BSR (British Society for Rheumatology). Calcium supplements are recommended for patients with severe SSc. New guidelines for the medicinal treatment of SSc have been published by the EULAR (European Alliance of Associations for Rheumatology) and the BSR (British Society for Rheumatology). Calcium channel blockers (CCBs) are recommended for initial therapy, along with phosphodiesterase-5 inhibitors (PDE5 inhibitors) and prostanoids. CCBs do not appear to offer any benefits in cases of finger necrosis. In addition to PDE5 inhibitors, prostanoids, and the endothelin antagonist bosentan, botulinum A toxin can also be applied locally. This is currently only recommended by the British guidelines. A significant placebo effect must be taken into account with RP. Euphoric case studies are often contrasted with sobering controlled studies. Local application of fat, connective tissue, and stem cells derived from adipose tissue could improve pain and impairment of hand function in RP patients with SSc.
Keywords:
Raynaud's phenomenon
systemic sclerosis
capillaroscopy
cold exposure
stem cell therapy
Raynaud's phenomenon
systemic sclerosis
capillaroscopy
cold exposure
stem cell therapy

Journal

A
Aktuelle Dermatologie
IF:
0
Papers:
60
Citations:
0

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No organization information available