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Upregulated Macrophage-inducible C-type Lectin on Intermediate Monocyte Facilitates T helper 17 cell Differentiation in Systemic Lupus Erythematosus
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DOI：10.1016/j.imlet.2026.107181.png)
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Abstract
En 中文
• Mincle expression is significantly upregulated in SLE, particularly on circulating intermediate monocytes (CD14⁺CD16⁺), and correlates with elevated serum IgG and κ-light chain levels. • Intermediate monocytes with increased Mincle expression promote Th17 differentiation, linking monocyte activation to pathogenic T cell responses in SLE. • Functional assays in THP-1 and U937 models demonstrate that Mincle facilitates Th1/Th17 polarization, suggesting that Mincle-driven monocyte-T cell interaction contributes to systemic inflammation and SLE progression.
Keywords:
Mincle
Intermediate monocytes
Th17 differentiation
Systemic Lupus Erythematosus
Monocyte-T cell interaction
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