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Uridine cytidine kinase 1 promotes phosphatidylcholine biosynthesis, facilitating SARS-CoV-2 infection

delete2026-07-21
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OA
AI
G
Guangda Shi
J
Jaeseung Lee
S
Smita Bhutda
Z
Zienab Etwebi
J
Jesse Miller
K
Kasirajan Ayyanathan
Y
Yongkang Li
D
David Nguyen
Y
Yongqing Zhu
W
Wujuan Zhang
A
Aaron R. Goldman
D
David C. Schultz
S
Sara Cherry *
DOI：10.1016/j.molcel.2026.06.040delete
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Abstract

Abstract

En 中文
• UCK1, but not UCK2, is required for SARS-CoV-2 replication • UCK2 salvage of cytoplasmic pyrimidines compensates for de novo biosynthesis • UCK1 metabolizes nuclear pyrimidines, driving phosphatidylcholine (PC) biosynthesis • UCK1 regulates peroxisome-derived lipids and peroxisome-DMV associations
Keywords:
SARS-CoV-2
metabolism
nucleotide biosynthesis
pyrimidine salvage
phosphatidylcholine
Kennedy pathway
lipidomics
peroxisomes
double-membrane vesicle
DMV
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Molecular Cell cover
Molecular Cell
IF:
16.6
Papers:
1.0W
Citations:
8.5W

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Wistar Institute cover
Wistar Institute
Scholars:
1.9K
Papers: 1.4K
Citations: 3.4K
U
University of Pennsylvania
Scholars:
1.0W
Papers: 3.7K
Citations: 11.8W
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