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Vascular leakage in non-small cell lung cancer is associated with immune evasion and poor response to immunotherapy
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DOI：10.1016/j.canlet.2026.218728.png)
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Abstract
En 中文
• Fibrinopeptide-A marks sites of active vascular leakage in human NSCLC • Intratumoral vascular leakage occurs within spatially discrete stromal niches • Regional leakage is driven by tumor VEGF-A, enabled by loss of endothelial PTPRB • Leakage-associated immunosuppression is linked with formation of Treg-enriched TLS • Vascular leakage predicts poor overall survival and reduced immunotherapy response
Keywords:
Non-small cell lung cancer
vascular leakage
fibrinopeptide A
VEPTP
tertiary lymphoid structures
immunotherapy response
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