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Vasoactive intestinal peptide attenuates form-deprivation myopia in guinea pigs by suppressing the Wnt/β-catenin pathway along the retina-choroid-scleral axis
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DOI：10.1016/j.exer.2026.111037.png)
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Abstract
En 中文
• Dose-dependent myopia inhibition by VIP is mediated via the scleral Wnt/β-catenin pathway. • VIP down-regulates the aberrantly activated scleral Wnt/β-catenin pathway. • VIP restores the irregular collagen arrangement in myopic sclera. • This study identifies a novel target (VIP) for potential myopia control therapy.
Keywords:
VIP
myopia
Wnt/β-catenin pathway
sclera
collagen arrangement
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