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Vibrational Spectroscopy as a Complementary Approach to Monitor SH-SY5Y Cell Differentiation

delete2026-04-27
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PRE
AI
I
Idália Almeida
F
Filipa Martins
B
Brian J. Goodfellow
S
Sandra Rebelo
A
Alexandra Nunes *
DOI：10.1016/j.ab.2026.116139delete
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Abstract

Abstract

En 中文
• Differentiation of SH-SY5Y cells confirmed by morphology, β-III-tubulin, and FTIR. • Spectroscopic profiles differ across 3050–900 cm-1 regions with cell DIVs. • Lipid, nucleic acid, and protein peak intensities vary with differentiation timepoints. • FTIR-ATR captures metabolomic changes in SH-SY5Y during in vitro differentiation.
Keywords:
SH-SY5Y cells
cell differentiation
FTIR spectroscopy
metabolomic changes
vibrational spectroscopy

Journal

Analytical Biochemistry cover
Analytical Biochemistry
IF:
2.5
Papers:
272
Citations:
3.3W

Organization

U
University of Aveiro
Scholars:
1.7K
Papers: 671
Citations: 1.7W
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