Viral miR-004-5p Hijacks Host Exosomes to Suppress TBK1-Mediated Antiviral Immunity During Koi Herpes Virus Infection

null Guo

doi:10.1016/j.fsi.2026.111651

Viral miR-004-5p Hijacks Host Exosomes to Suppress TBK1-Mediated Antiviral Immunity During Koi Herpes Virus Infection

2026-08-14

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AI

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null Guo

N

null Peng

N

null Lai

N

null Fan

N

null Wang

N

null Qin

N

null Yang *

N

null Lee *

DOI：10.1016/j.fsi.2026.111651

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Abstract

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• To our knowledge, this study is the first report focusing on exosome-delivered viral miRNA mediating host immune escape during KHV infection in fish; • We clarified a complete regulatory axis: exosomal miR-004-5p -TBK1 suppression - inhibited IFN-I signaling / enhanced autophagy - KHV immune escape; • Different from previous studies focusing on host-derived exosomal miRNAs in aquatic animals, our work reveals that KHV hijacks host exosomal system to transport self-encoded miRNA for viral infection, filling a critical research gap in fish virology.

Keywords:

KHV

Exosomes

Immune evasion

Viral miR-004-5p Hijacks Host Exosomes to Suppress TBK1-Mediated Antiviral Immunity During Koi Herpes Virus Infection

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