Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B

Eric Johansen

doi:10.1126/scisignal.adr8554

Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B

2026-06-16

0

PRE

AI

E

Eric Johansen

G

Guan‐Da Syu

Z

Zijian Wan

D

Dylan C. Sarver

M

Meng Ding

X

Xinzhong Dong

S

Shaopeng Wang

G

G. William Wong *

H

Heng Zhu *

DOI：10.1126/scisignal.adr8554

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GPRC5B is an orphan G protein–coupled receptor (GPCR) found on adipocytes, and GPRC5B-deficient mice are resistant to high-fat diet–induced obesity and have reduced adipose inflammation. Using a virion-based GPCR expression system combined with human protein microarrays, Johansen et al. identified the macrophage glycoprotein MD-1 as a potential endogenous GPRC5B agonist. Biochemical and functional assays showed that MD-1 stimulated Gαs-dependent signaling through GPRC5B, and cell-cell contact experiments between macrophage and adipocyte cell lines in vitro showed that MD-1 stimulated lipolysis in adipocytes, suggesting that this pathway should be investigated for therapeutic potential in obesity. —John F. Foley

Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B

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