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Vitamin D and frailty: Clinical evidence, mechanistic insights, and translational challenges
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DOI：10.1016/j.metabol.2026.156697.png)
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Abstract
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• Vitamin D emerges as a pleiotropic regulator of frailty-related domains that determine physiological reserve in aging. • Observational and longitudinal evidence: low 25(OH)D levels are linked to frailty, pre-frailty, and adverse outcome. • Randomized controlled trials: vitamin D supplementation mainly benefits deficient, frail, or institutionalized older adults. • Study heterogeneity may explain variable trials results and support targeted approaches in vitamin D–deficient individuals.
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