.png){kind=icon}
.png){kind=icon}
Return
Vitamin D attenuates metabolic dysfunction-associated steatotic liver disease (MASLD) and downregulates hepatic gluconeogenesis in obesity
.png){kind=icon}
PRE
AI
M
N
V
G
A
D
M
A
L
A
J
DOI：10.1016/j.jnutbio.2026.110450.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to vitamin D deficiency. • MASLD is linked to insulin resistance (IR) and abnormal activation of hepatic gluconeogenesis. • Vitamin D supplementation improves IR and MASLD in cafeteria diet-induced obese rats. • Vitamin D supplementation reduced the higher gluconeogenesis and glycogenolysis of obese rats. • Vitamin D may reduce hepatic glucose output and help control hyperglycemia in obese individuals.
Keywords:
vitamin D
insulin resistance
MASLD
gluconeogenesis
vitamin D receptor
hepatic metabolism
SIRT1
25(OH)D
,
25-hydroxyvitamin D
1,24,25(OH)₃D
,
1,24,25-trihidroxivitamina D or calcitriol
AKT
,
protein kinase B
ALT
,
alanine aminotransferase
AST
,
aspartate aminotransferase
ATGL
,
adipose triglyceride lipase
CHOL
,
cholesterol
CYP2R1
,
cytochrome P450 2R1
CYP24A1
,
cytochrome P450 24A1
DCFA
,
2′,7′-dichlorofluorescein
DTNB
,
5,5′-dithiobis(2-nitrobenzoic acid)
FAS
,
fatty acid synthase
FGF21
,
fibroblast growth factor 21
FRAP
,
ferric reducing antioxidant power
G6Pase
,
glucose-6-phosphatase
GSH
,
reduced glutathione
GSSG
,
oxidized glutathione
GST
,
glutathione S-transferase
HDL
,
high-density lipoprotein cholesterol
HO-1
,
heme oxygenase 1
HSL
,
hormone-sensitive lipase
IR
,
insulin resistance
IL-1β
,
interleukin 1 beta
IL-6
,
interleukin 6
IL-10
,
interleukin 10
IRS-2
,
insulin receptor substrate-2
ITT
,
insulin tolerance test
LDL
,
low-density lipoprotein cholesterol
LPS
,
lipopolysaccharides
MASLD
,
metabolic dysfunction-associated steatotic liver disease
MPO
,
myeloperoxidase
NF-κB
,
nuclear factor-kappa B
Nrf2
,
nuclear factor erythroid 2-related factor 2
OGTT
,
oral glucose tolerance test
PEPCK
,
phosphoenolpyruvate carboxykinase
PGC-1α
,
peroxisome proliferator-activated receptor gamma coactivator-1 alpha
PPARα and PPARγ
,
peroxisome proliferator-activated receptor alpha and gamma
PYY
,
peptide tyrosine tyrosine
ROS
,
reactive oxygen species
SIRT1
,
sirtuin 1
SOD
,
superoxide dismutase
SREBP-1c
,
sterol regulatory element binding protein-1c
TAC
,
total antioxidant capacity
TBARS
,
thiobarbituric acid reactive substances
TGL
,
triglycerides
TNFα
,
tumor necrosis factor alpha
VDR
,
vitamin D receptor
Journal
IF:
4.9
Papers:
4.5K
Citations:
1.4W
Organization
Cited Papers