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Vitamin D deficiency alters prostate epithelial differentiation and increases prostate cancer aggressiveness in ex vivo and in vivo models

delete2026-07-31
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OA
AI
A
Adriana Duraki
K
Kirsten D. Krieger
S
Sasha Celada
R
Robert A. Holt
R
Ryan M. Brown
L
Luyu Wang
M
Michael J. Schlicht
M
Maarten C. Bosland
R
Robert M. Sargis
D
Donald Vander Griend
L
Larisa Nonn *
DOI:10.1016/j.canlet.2026.218732delete
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Abstract

Abstract

En 中文
• Vitamin D enhances prostate epithelial differentiation ex vivo • 6-month dietary vitamin D deficiency alters prostate gene expression in vivo • 6 months of adaptation to vitamin D blocks MDA-PCa-2b xenograft growth • Maintenance in vitamin D media alters androgen signaling in prostate cancer cells
Keywords:
prostate
vitamin D
differentiation
epithelial
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Cancer Letters cover
Cancer Letters
IF:
10.1
Papers:
1.7W
Citations:
4.3W

Organization

D
department of pathology
Scholars:
1.2K
Papers: 603
Citations: 0
D
Department of Medicine
Scholars:
8.1K
Papers: 3.4K
Citations: 33
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