.png){kind=icon}
.png){kind=icon}
Return
Vitamin D supplementation and calcium absorption during caloric restriction: a randomized double-blind trial
.png){kind=icon}
OA
AI
S
D
S
Y
R
M
H
DOI：10.3945/ajcn.112.044909.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Background: Weight loss (WL) is associated with a decrease in calcium absorption and may be one mechanism that induces bone loss with weight reduction. Objective: Because vitamin D supplementation has been shown to increase true fractional calcium absorption (TFCA), the goal of this study was to examine the effect of vitamin D during WL or weight maintenance (WM). Design: A randomized, placebo-controlled, double-blind 6-wk study was conducted in 82 postmenopausal women [BMI (in kg/m(2); +/- SD): 30.2 +/- 3.7] with 25-hydroxyvitamin D [25(OH)D] concentrations <70 nmol/L during either WL or WM. All women were given 10 mu g vitamin D-3/d and 1.2 g Ca/d and either weekly vitamin D-3 (375 mu g) or a placebo equivalent to 63 mu g (2500 IU)/d and 10 mu g (400 IU)/d, respectively. We measured TFCA with the use of dual-stable isotopes, 25(OH)D, parathyroid hormone, estradiol, calcitriol, and urinary calcium at baseline and 6 wk in weight loss and vitamin D-3-supplementation (WL-D; n = 19), weight maintenance and vitamin D-3-supplementation (WM-D; n = 20), weight loss and placebo (n = 22), and weight maintenance and placebo (n = 21) groups. Results: WL groups lost 3.8 +/- 1.1% of weight with no difference between vitamin D-3 supplementation and the placebo. The rise in serum 25(OH)D was greatest in the WL-D group (19.8 +/- 14.5 nmol/L) compared with in WM-D (9.1 +/- 10.3 nmol/L) and placebo groups (1.5 +/- 10.9 nmol/L). TFCA increased with vitamin D-3 supplementation compared with placebo treatment (P < 0.01) and decreased during WL compared with WM. Serum 25(OH)D or 1,25-dihyroxyvitamin D did not correlate with TFCA. Conclusion: These data show that vitamin D supplementation increases TFCA and that WL decreases TFCA and suggest that, when calcium intake is 1.2 g/d, either 10 or 63 mu g vitamin Did is sufficient to maintain the calcium balance. This trial was registered at clinical-trials.gov as NCT00473031. Am J Clin Nutr 2013;97:637-45.
Keywords:
OVERWEIGHT POSTMENOPAUSAL WOMEN
WEIGHT-LOSS
D INSUFFICIENCY
ELDERLY-WOMEN
D METABOLITES
OLDER WOMEN
LOSE BONE
BODY-SIZE
EFFICIENCY
OBESITY
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
6.9
Papers:
1.1W
Citations:
5.3W