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Vitreous humor–mimetic liposomes enable effective gene delivery to the eye via intravitreal injection

delete2026-04-21
delete0
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OA
AI
S
So Young Choi
C
Chang Sik Cho
S
Seongchan Kim
J
Jeong Hun Kim
H
Hyunkyung Kim *
K
Ki Hun Kim *
D
Dong Hyun Jo *
H
Hyojin Lee *
DOI：10.1016/j.biomaterials.2026.124226delete
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Abstract

Abstract

En 中文
• Vitreous humor–mimetic liposomes (VML) enhance pGFP transfection efficiency via intravitreal injection • VML show lower toxicity and higher pGFP transfection efficiency in vivo • pGFP-NDP-encapsulating VML successfully restored vascularization in Ndp-hemizygous and oxygen induced retinopathy (OIR) mouse models.
Keywords:
vitreous
liposome
gene delivery
intravitreal injection
ocular therapy
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Biomaterials cover
Biomaterials
IF:
12.9
Papers:
1.9W
Citations:
10.8W

Organization

K
Korea University
Scholars:
3.6W
Papers: 3.8W
Citations: 4.4W
S
seoul national university
Scholars:
5.4K
Papers: 2.0K
Citations: 0
K
korea institute of science and technology
Scholars:
1.8K
Papers: 688
Citations: 1
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