Voltage-Gated Sodium Channels in Pain: Which Channels, Which Blockers, and Where NaV1.7 Fits

null Sutemieva

doi:10.1016/j.pbiomolbio.2026.04.001

Voltage-Gated Sodium Channels in Pain: Which Channels, Which Blockers, and Where NaV1.7 Fits

2026-04-27

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null Sutemieva

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null Sobenin

DOI：10.1016/j.pbiomolbio.2026.04.001

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• The review integrates NaV1.7 channel structure, gating and physiological function with its pharmacological blockade in a single framework, bringing together channel fundamentals and therapeutic inhibition logic. • NaV1.7-directed strategies are organized in a sequential and accessible way, from pore blockers and toxin-based modulators to VSD4-targeted ligands, targeted degradation, epigenetic repression and partner-directed regulatory approaches. • The review concludes with an integrated discussion of translational barriers and converging future strategies for advancing NaV1.7-directed analgesia.

Keywords:

NaV1.7

voltage-gated sodium channels

pain

pharmacological blockade

analgesia

Voltage-Gated Sodium Channels in Pain: Which Channels, Which Blockers, and Where NaV1.7 Fits

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