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Warhead assembly in a lethal pathogen
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DOI：10.1038/s41557-022-01013-z.png)
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Abstract
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Malleicyprols are highly reactive polyketides responsible for virulence in some pathogenic bacteria. Now, the enzyme that constructs the cyclopropanol warhead of malleicyprols has been identified. This enzyme could represent a useful target for developing new antivirulence therapeutics.
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20.2
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4.4K
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Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.png)
NATURE CHEMISTRY
OAAI
NATURE CHEMISTRYIF20.2
OAAIShareSaveShareSaveShareSaveDiscovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial OriginOAAI
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