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Water-Soluble Viscosity-Activated Molecular Rotor for In Situ Imaging of Liver Damage in the NIR-II Window
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DOI：10.1021/acssensors.6c00771.png)
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Abstract
En 中文
Microviscosity in the hepatic microenvironment changes during steatosis, matrix remodeling, and drug-induced injury but remains challenging to monitor in vivo. Here, we report JMR-1002-PEG, a water-soluble near-infrared II (NIR-II, 1000−1700 nm) fluorescent molecular rotor for viscosity-responsive liver imaging. The design of JMR-1002-PEG hinges on the strategic optimization of the donor−π−acceptor structure, where achieving NIR-II emission required careful modulation of the conjugated system while maintaining sufficient flexibility for viscosity-sensitive behavior. In mice, the probe reports hepatic microviscosity changes in acetaminophen-induced acute injury, CCl4-induced fibrosis, and diet/drug-induced steatosis. Signal changes correlate with standard biochemical and histological markers and decrease after treatment. These findings identify PEGylated NIR-II molecular rotors as promising tools for noninvasive, real-time mechanism-based assessment of liver disease.
Keywords:
Anatomy
Biological imaging
Fluorescence
Fluorescence imaging
Viscosity
liver damage
molecular rotors
near-infrared II
viscosity
donor−π−acceptor
bioimaging
Journal
IF:
9.1
Papers:
975
Citations:
2.6W
Organization
Cited Papers