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WaveFlex Biosensor: A Flexible-Shaped Plasmonic Optical Fiber Sensor for Histamine Detection
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DOI：10.1109/JSEN.2023.3305464.png)
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Abstract
En 中文
In this work, a combination of simulation and experiment is used to analyze the distribution of the evanescent field in a W-shaped optical fiber. A novel flexible W-shaped optical fiber (FWOF) biosensor based on the localized surface plasmon resonance (LSPR) effect (also known as a WaveFlex biosensor) is designed and fabricated for detecting histamine in food. First, gold nanoparticles (AuNPs) are immobilized on the FWOF probe's surface to excite the LSPR effect. Second, niobium carbide (Nb-2 CTx) MXene and molybdenum disulfide nanoparticles (MoS2 NPs) are immobilized on the sensing area of the FWOF probe to improve the reaction area. A larger surface area can offer more immobilization sites for biomolecules. Meanwhile, to enhance the specificity of the sensing probe, the diamine oxidase (DAO) enzyme is functionalized on the nanomaterials (NMs)-immobilized probe. The absorption spectrum and microscopic distribution of the nanoparticles are characterized and measured using an ultraviolet-visible (UV-Vis) spectrophotometer and a high-resolution transmission electron microscope. The immobilization results of NMs on the probe surface are verified by scanning electron microscopy. In order to further explore the performance of the sensor, pH testing, stability testing, reproducibility, repeatability, and probe specificity testing are also carried out. The proposed sensor has a linear detection range of 0-1000 mu M, a detection limit of 52.5 mu M, and a sensitivity of 4.4 pm/mu M.
Keywords:
Sensors
Optical fiber sensors
Biosensors
Optical surface waves
Probes
Optical fibers
Surface treatment
Histamine detection
localized surface plasmon resonance (LSPR)
optical fiber sensor
WaveFlex biosensor
W-shaped optical fiber
Journal
IF:
4.5
Papers:
2.1W
Citations:
7.3W