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wbp-encoded LPS O-antigen architecture as a prognostic and therapeutic target in Pseudomonas aeruginosa keratitis
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DOI：10.1016/j.ebiom.2026.106425.png)
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Abstract
En 中文
Pseudomonas aeruginosa (P. aeruginosa) keratitis can progress rapidly to vision-threatening disease, even with intensive therapy. Virulence-associated genes are key determinants of ocular-surface pathogenesis. We therefore sought to develop a composite wbp-exo genotyping framework for risk stratification and to guide wbp-dependent, LPS-directed, levofloxacin-polymyxin B (LVX-POL) combination therapy for high-risk corneal infections.
Keywords:
Pseudomonas aeruginosa
Whole-genome sequencing
wbp gene
Lipopolysaccharide
Bacterial keratitis
Polymyxin B
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