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What does time mean in development?
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DOI：10.1242/dev.164368.png)
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Abstract
En 中文
Biology is dynamic. Timescales range from frenetic sub-second ion fluxes and enzymatic reactions to the glacial millions of years of evolutionary change. Falling somewhere in the middle of this range are the processes we usually study in development: cell division and differentiation, gene expression, cell-cell signalling, and morphogenesis. But what sets the tempo and manages the order of developmental events? Are the order and tempo different between species? How is the sequence of multiple events coordinated? Here, we discuss the importance of time for developing embryos, highlighting the necessity for global as well as cell-autonomous control. New reagents and tools in imaging and genomic engineering, combined with in vitro culture, are beginning to offer fresh perspectives and molecular insight into the origin and mechanisms of developmental time.
Keywords:
STEM-CELLS
CAENORHABDITIS-ELEGANS
SEGMENTATION CLOCK
TEMPORAL IDENTITY
MOUSE
DYNAMICS
GROWTH
CLK-1
GENE
DIFFERENTIATION