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When aging becomes degeneration: Evidence from Metabolomics of Healthy Age-stratified organ-donor and degenerated lumbar discs.
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DOI：10.1016/j.spinee.2026.05.010.png)
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Abstract
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Aging and degeneration are biologically distinct processes in intervertebral discs, but are difficult to differentiate radiologically. Metabolomics reflects real-time biochemical activity, and age-stratified metabolomic profiling of normal and degenerated discs may identify preclinical degeneration and reveal molecular signatures distinguishing normal aging from degeneration.
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