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White matter changes with age utilizing quantitative diffusion MRI
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DOI：10.1212/WNL.0000000000000597.png)
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Abstract
En 中文
Objective: To investigate the relationship between older age and mean cerebral white matter fiber bundle lengths (FBLs) in specific white matter tracts in the brain using quantified diffusion MRI. Methods: Sixty-three healthy adults older than 50 years underwent diffusion tensor imaging. Tractography tracings of cerebral white matter fiber bundles were derived from the diffusion tensor imaging data. Results: Results revealed significantly shorter FBLs in the anterior thalamic radiation for every 1-year increase over the age of 50 years. Conclusions: We investigated the effects of age on FBL in specific white matter tracts in the brains of healthy older individuals utilizing quantified diffusion MRI. The results revealed a significant inverse relationship between age and FBL. Longitudinal studies of FBL across a lifespan are needed to examine the specific changes to the integrity of white matter.
Keywords:
FIBER BUNDLE LENGTHS
HUMAN BRAIN
TRACTOGRAPHY METRICS
NERVE-FIBERS
TENSOR MRI
ANISOTROPY
IMAGES
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