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WISP-3 enhances proinflammatory cytokine IL-1β production in rheumatoid arthritis through the FAK, JNK and AP-1 pathways
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DOI：10.1016/j.cellimm.2026.105103.png)
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Abstract
En 中文
• WISP-3 significantly increases IL-1β expression in synovial cells in a dose-dependent manner. • WISP-3 activates the FAK/JNK/c-Jun signaling cascade to promote pro-inflammatory responses. • WISP-3–induced activation of c-Jun enhances its transcriptional activity, driving IL-1β production.
Keywords:
WISP-3
IL-1β
FAK/JNK/c-Jun signaling
rheumatoid arthritis
AP-1 pathway
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