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Withanolides from Physalis hispida

delete2014-01-23
delete26
PRE
AI
C
Cong-Mei Cao
张华平 cover
张华平 (Huaping Zhang)
R
Robert J. Gallagher
V
Victor W. Day
K
Kelly Kindscher
P
Patrick T. Grogan
M
Mark S. Cohen
B
Barbara N. Timmermann *
DOI:10.1021/np400953ndelete
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Abstract

Abstract

En 中文
Nine new withanolides (1-9), withahisolides A-I, were isolated along with nine known compounds (10-18) from the aerial parts of Physalis hispida. The structures of 1-9 were elucidated through a variety of spectroscopic techniques, while the structures of 1 and 2 were confirmed by X-ray crystallographic analysis. Compounds 1-3 are the first withanolides with nonaromatic six-membered ring D moieties. In addition, withanolide 8 represents a novel withanolide skeleton due to the absence of a C-13-C-17 bond within the steroidal nucleus.
Keywords:
SALPICHROA-ORIGANIFOLIA
NICANDRA-PHYSALOIDES
ANTIPROLIFERATIVE WITHANOLIDES
SOLANACEAE
STEROIDS

Journal

Journal of Natural Products cover
Journal of Natural Products
IF:
3.6
Papers:
1.2W
Citations:
2.9W

Organization

U
University of Kansas
Scholars:
1.9W
Papers: 1.7W
Citations: 8.1K
U
university of michigan system
Scholars:
9.1W
Papers: 8.6W
Citations: 133