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Wnt4 as a signal coordinates DNA methylation and acetylation to determine germ line fate
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DOI：10.1016/j.ydbio.2026.04.015.png)
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Abstract
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• Absence of Wnt4 signaling in female embryonic germ cells maintains the germ cells in the G1-GO and S phases like in male germ cells • Wnt4 signaling induces meiosis progression of meiosis entry by reducing DNMT3a, DNMT1 and 5mC markers in female germ cells • Wnt4 signaling is necessary for removing the methylation of Sycp3 promoter allowing Sycp3 to be expressed when the germ cells progress into meiosis • Wnt4 signaling plays a crucial role in regulating the delicate balance between DNA methylation and acetylation in female germ cells.
Keywords:
Wnt4
DNA methylation
meiosis
germ cells
acetylation
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2.1
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393
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2.2W
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