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Y chromothripsis?
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DOI：10.1038/ncb3458.png)
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Abstract
En 中文
Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining.
Keywords:
CHROMOSOME-PULVERIZATION
DNA-DAMAGE
MICRONUCLEI
CELLS
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