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YAP mediates activation of the serine synthesis pathway in the heart during pressure overload
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DOI：10.1016/j.yjmcc.2026.06.002.png)
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Abstract
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• YAP upregulates components of the serine synthesis pathway (SSP). • Pressure overload upregulates the SSP through YAP. • YAP upregulates ASC-1, a serine transporter. • Both the SSP and ASC-1 mediate YAP-induced cardiac hypertrophy. • YAP directly upregulates SSP genes through interaction with TEAD1.
Keywords:
Cardiac hypertrophy
Serine
YAP
Serine synthesis pathway
Pressure overload
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