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YAP plays a critical role in myocardial recovery from myocarditis by suppressing IFN-γ signaling pathway

delete2026-07-06
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PRE
AI
Y
Yusuke Kametani
M
Masanori Obana
A
Ayaka Umeda
K
Kaho Egawa
K
Kosuke Nishinaka
S
Shota Tanaka
J
Junichi Sadoshima
S
Soichiro Fukada
Y
Yasushi Fujio
DOI：10.1093/cvr/cvag151delete
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Abstract

Abstract

En 中文
Despite the limited resilience of adult mammalian hearts, the heart damaged by inflammation naturally heals in a majority of patients with myocarditis. Therefore, therapeutic activation of intrinsic healing capacity of the heart would be promising as regenerative medicine. Yes-associated protein 1 (YAP) determines organ size by regulating cell proliferation. However, the physiological roles of YAP activation in adult mammalian cardiomyocytes remain unclear. This study aimed to investigate the role of endogenous YAP activation in cardiac remodeling during myocarditis to clarify the molecular mechanisms underlying myocardial recovery.

Journal

Cardiovascular Research cover
Cardiovascular Research
IF:
13.3
Papers:
1.2W
Citations:
2.8W

Organization

R
rutgers university
Scholars:
1.2K
Papers: 700
Citations: 0
T
the university of osaka
Scholars:
2.8W
Papers: 1.8W
Citations: 6
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