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Your neighbors matter: Adjacent cancer cells dampen TLS function
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DOI：10.1016/j.ccell.2026.06.011.png)
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Abstract
En 中文
In this issue of Cancer Cell, Hernández-Verdin et al. reveal why some tumors with tertiary lymphoid structures (TLSs) resist immunotherapy: their findings identify cancer-derived gamma-aminobutyric acid (GABA) as an immunosuppressant factor resulting in dysfunctional TLS and immunotherapy resistance. Targeting GABA with immunotherapy reshapes the tumor and TLS microenvironment and ultimately improves therapeutic efficacy.
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