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Zearalenone accelerates aging and mitochondrial dysfunction: Evidence from network toxicology and zebrafish models
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DOI：10.1016/j.cbpc.2025.110325.png)
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Abstract
En 中文
• ZEN accelerates aging and induces mitochondrial dysfunction via AKT1, MAPK3, TP53, and NFKB1. • Molecular docking confirms binding affinities, linking ZEN to aging pathways. • Zebrafish exposed to ZEN show developmental toxicity, muscle degeneration, and impaired locomotion. • Transcriptomics reveal dysregulation of aging markers (igf1, nfkb2, sirt1). • Study underscores public health risks of ZEN, advocating stricter food monitoring.
Keywords:
Zearalenone
aging
mitochondrial dysfunction
AKT1
MAPK3
TP53
NFKB1
transcriptomics
zebrafish
public health
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