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ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation
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DOI：10.1016/j.stem.2026.05.009.png)
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Abstract
En 中文
• ZNF512B safeguards genome integrity at key regulatory regions • ZNF512B suppresses cGAS-STING signaling and SASP-associated inflammation • ZNF512B recruits NuRD to damaged chromatin to enable efficient DNA repair • ZNF512B limits inflammation in neuromuscular organoids and liver injury
Keywords:
genome integrity
DNA repair
senescence
senescence-associated secretory phenotype
SASP
inflammation
CRISPR-Cas9 screening
ZNF512B
chromatin remodeling
amyotrophic lateral sclerosis
neuromuscular organoids
Journal
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20.4
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3.6K
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3.1W
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