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AZD7798, a monoclonal antibody depleting CCR9+T cells, with the potential to target hard-to-treat small bowel Crohn's disease Powell, N.; Hedin, C.; Harper, A. R.; Mackay, J.; Lundin, P.; Bock, D.; Spata, E.; Bouma, G.; Tian, S.; Lundahl, A.; Lund, J.; Eck, S.; Popinska, A.; Strombeck, A.; Fowler, A.; Eberhardson, M.; Belvisi, M.; Marks, D. J. B. Share Save
APATURA: a Phase 2a study of elarekibep, an inhaled IL-4 receptor alpha inhibitor, in moderate-to-severe asthma Hugo, Tania; Harper, Andrew R.; Leander, Jacob; Lundin, Pa; Bock, David; Zhou, Xiao-Hong; Bondarenko, Irina; Burns, Steve; Wiegert, Erol; Fitzgerald, Mary F.; Close, David R.; Keeling, David J.; Pandya, Hitesh; Belvisi, Maria G.; O'Byrne, Paul M. Share Save
Disease prediction with multi-omics and biomarkers empowers case-control genetic discoveries in the UK Biobank Garg, Manik; Karpinski, Marcin; Matelska, Dorota; Middleton, Lawrence; Burren, Oliver S.; Hu, Fengyuan; Wheeler, Eleanor; Smith, Katherine R.; Fabre, Margarete A.; Mitchell, Jonathan; O'Neill, Amanda; Ashley, Euan A.; Harper, Andrew R.; Wang, Quanli; Dhindsa, Ryan S.; Petrovski, Slave; Vitsios, Dimitrios Share Save
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Phenome-wide identification of therapeutic genetic targets, leveraging knowledge graphs, graph neural networks, and UK Biobank data Middleton, Lawrence; Melas, Ioannis; Vasavda, Chirag; Raies, Arwa; Rozemberczki, Benedek; Dhindsa, Ryan S.; Dhindsa, Justin S.; Weido, Blake; Wang, Quanli; Harper, Andrew R.; Edwards, Gavin; Petrovski, Slave; Vitsios, Dimitrios Share Save
Climatological reference stations: Definitions and requirements Merlone, Andrea; Beges, Gaber; Bottacin, Alberto; Brunet, Manola; Gilabert, Alba; Groselj, Drago; Harper, Andrew; Hechler, Peer; Ivanov, Mirjana; Musacchio, Chiara; Trewin, Blair; Wright, William Share Save
Evaluation of ACCEPT to predict COPD exacerbations in NOVELTY Lewis, Samuel; Taylor, Adam; Rapsomaniki, Eleni; Mullerova, Hana; Kristensson, Cecilia; Harper, Andrew; Burgel, Pierre-Regis; Sadatsafavi, Mohsen; Owen, Caroline; Hughes, Rod Share Save
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The penetrance of rare variants in cardiomyopathy-associated genes: A cross-sectional approach to estimating penetrance for secondary findings Mcgurk, Kathryn A.; Zhang, Xiaolei; Theotokis, Pantazis; Thomson, Kate; Harper, Andrew; Buchan, Rachel J.; Mazaika, Erica; Ormondroyd, Elizabeth; Wright, William T.; Macaya, Daniela; Pua, Chee Jian; Funke, Birgit; Macarthur, Daniel G.; Prasad, Sanjay K.; Cook, Stuart A.; Allouba, Mona; Aguib, Yasmine; Yacoub, Magdi H.; O'Regan, Declan P.; Barton, Paul J. R.; Watkins, Hugh; Bottolo, Leonardo; Ware, James S. Share Save
DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets (vol 5, 1291, 2022) Raies, Arwa; Tulodziecka, Ewa; Stainer, James; Middleton, Lawrence; Dhindsa, Ryan S. S.; Hill, Pamela; Engkvist, Ola; Harper, Andrew R. R.; Petrovski, Slave; Vitsios, Dimitrios Share Save
Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy Yu, Mengyao; Harper, Andrew R.; Aguirre, Matthew; Pittman, Maureen; Tcheandjieu, Catherine; Amgalan, Dulguun; Grace, Christopher; Goel, Anuj; Farrall, Martin; Xiao, Ke; Engreitz, Jesse; Pollard, Katherine S.; Watkins, Hugh; Priest, James R. Share Save
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease Young, William J.; Haessler, Jeffrey; Benjamins, Jan-Walter; Repetto, Linda; Yao, Jie; Isaacs, Aaron; Harper, Andrew R.; Ramirez, Julia; Garnier, Sophie; van Duijvenboden, Stefan; Baldassari, Antoine R.; Concas, Maria Pina; Duong, ThuyVy; Foco, Luisa; Isaksen, Jonas L.; Mei, Hao; Noordam, Raymond; Nursyifa, Casia; Richmond, Anne; Santolalla, Meddly L.; Sitlani, Colleen M.; Soroush, Negin; Theriault, Sebastien; Trompet, Stella; Aeschbacher, Stefanie; Ahmadizar, Fariba; Alonso, Alvaro; Brody, Jennifer A.; Campbell, Archie; Correa, Adolfo; Darbar, Dawood; De Luca, Antonio; Deleuze, Jean-Francois; Ellervik, Christina; Fuchsberger, Christian; Goel, Anuj; Grace, Christopher; Guo, Xiuqing; Hansen, Torben; Heckbert, Susan R.; Jackson, Rebecca D.; Kors, Jan A.; Lima-Costa, Maria Fernanda; Linneberg, Allan; Macfarlane, Peter W.; Morrison, Alanna C.; Navarro, Pau; Porteous, David J.; Pramstaller, Peter P.; Reiner, Alexander P.; Risch, Lorenz; Schotten, Ulrich; Shen, Xia; Sinagra, Gianfranco; Soliman, Elsayed Z.; Stoll, Monika; Tarazona-Santos, Eduardo; Tinker, Andrew; Trajanoska, Katerina; Villard, Eric; Warren, Helen R.; Whitsel, Eric A.; Wiggins, Kerri L.; Arking, Dan E.; Avery, Christy L.; Conen, David; Girotto, Giorgia; Grarup, Niels; Hayward, Caroline; Jukema, J. Wouter; Mook-Kanamori, Dennis O.; Olesen, Morten Salling; Padmanabhan, Sandosh; Psaty, Bruce M.; Pattaro, Cristian; Ribeiro, Antonio Luiz P.; Rotter, Jerome I.; Stricker, Bruno H.; van der Harst, Pim; van Duijn, Cornelia M.; Verweij, Niek; Wilson, James G.; Orini, Michele; Charron, Philippe; Watkins, Hugh; Kooperberg, Charles; Lin, Henry J.; Wilson, James F.; Kanters, Jrgen K.; Sotoodehnia, Nona; Mifsud, Borbala; Lambiase, Pier D.; Tereshchenko, Larisa G.; Munroe, Patricia B. Share Save
Effects of protein-coding variants on blood metabolite measurements and clinical biomarkers in the UK Biobank Nag, Abhishek; Dhindsa, Ryan S.; Middleton, Lawrence; Jiang, Xiao; Vitsios, Dimitrios; Wigmore, Eleanor; Allman, Erik L.; Reznichenko, Anna; Carss, Keren; Smith, Katherine R.; Wang, Quanli; Challis, Benjamin; Paul, Dirk S.; Harper, Andrew R.; Petrovski, Slave Share Save
Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy Aung, Nay; Lopes, Luis R.; van Duijvenboden, Stefan; Harper, Andrew R.; Goel, Anuj; Grace, Christopher; Ho, Carolyn Y.; Weintraub, William S.; Kramer, Christopher M.; Neubauer, Stefan; Watkins, Hugh C.; Petersen, Steffen E.; Munroe, Patricia B. Share Save
DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets Raies, Arwa; Tulodziecka, Ewa; Stainer, James; Middleton, Lawrence; Dhindsa, Ryan S.; Hill, Pamela; Engkvist, Ola; Harper, Andrew R.; Petrovski, Slave; Vitsios, Dimitrios Share Save
Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes Nag, Abhishek; Dhindsa, Ryan S.; Mitchell, Jonathan; Vasavda, Chirag; Harper, Andrew R.; Vitsios, Dimitrios; Ahnmark, Andrea; Bilican, Bilada; Madeyski-Bengtson, Katja; Zarrouki, Bader; Zoghbi, Anthony W.; Wang, Quanli; Smith, Katherine R.; Alegre-Diaz, Jesus; Kuri-Morales, Pablo; Berumen, Jaime; Tapia-Conyer, Roberto; Emberson, Jonathan; Torres, Jason M.; Collins, Rory; Smith, David M.; Challis, Benjamin; Paul, Dirk S.; Bohlooly-Y, Mohammad; Snowden, Mike; Baker, David; Fritsche-Danielson, Regina; Pangalos, Menelas N.; Petrovski, Slave Share Save
Cancer-driving mutations are enriched in genic regions intolerant to germline variation Vitsios, Dimitrios; Dhindsa, Ryan S.; Matelska, Dorota; Mitchell, Jonathan; Zou, Xuequing; Armenia, Joshua; Hu, Fengyuan; Wang, Quanli; Sidders, Ben; Harper, Andrew R.; Petrovski, Slave Share Save
A GWAS OF LGI1-ANTIBODY ENCEPHALITIS Binks, Sophie; Elliott, Kate; Sempere, Vicente; Castrillo, Sergio Muniz; Ambati, Aditya; Harper, Andrew; Honnorat, Jerome; Mignot, Emmanuel; Knight, Julian; Irani, Sarosh Share Save
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