Ada W.Y. Leung - Publications, H-index & Citations

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Ada W.Y. Leung

bc cancer research institute

17H-index

58Paper Count

865Citation Count

Published Papers 24

Publication Date

Liposomal Formulations of Metal-CX5461 complexes: Copper-CX5461 complexation mediates CX5461 degradation while Zinc-CX5461 formulations are suitable for development

Journal of Drug Delivery Science and Technology

IF4.9

2025-09-30

OAAI

Maryam Sharifiaghdam; XuXin Sun; Ada W.Y. Leung; Nancy Dos Santos; Nicole Wretham; Zeynab Nosrati; Marcel B. Bally

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Liposomal delivery of a disulfiram metabolite drives copper-mediated tumor immunity

International Journal of Pharmaceutics

IF5.2

2025-08-02

OAAI

Devon Heroux; Ada W.Y. Leung; Roger Gilabert-Oriol; Jayesh Kulkarni; Malathi Anantha; Pieter R. Cullis; Marcel B. Bally

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Liposomal Formulation of Hydroxychloroquine Can Inhibit Autophagy In Vivo

PHARMACEUTICS

IF5.5

2024-12-30

OAAI

Dragowska, Wieslawa H.; Singh, Jagbir; Wehbe, Mohamed; Anantha, Malathi; Edwards, Katarina; Gorski, Sharon M.; Bally, Marcel B.; Leung, Ada W. Y.

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Repurposing disulfiram for cancer: A drug delivery and population-based approach

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Heroux, Devon; Leung, Ada W.; Gilabert-Oriol, Roger; Bally, Marcel B.

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Characterization of a liposomal copper(II)-quercetin formulation suitable for parenteral use

DRUG DELIVERY AND TRANSLATIONAL RESEARCH

IF5.5

2019-09-03

OAAI

Chen, Kent T. J.; Anantha, Malathi; Leung, Ada W. Y.; Kulkarni, Jayesh A.; Militao, Gardenia G. C.; Wehbe, Mohamed; Sutherland, Brent; Cullis, Pieter R.; Bally, Marcel B.

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Recent Treatment Advances and the Role of Nanotechnology, Combination Products, and Immunotherapy in Changing the Therapeutic Landscape of Acute Myeloid Leukemia

PHARMACEUTICAL RESEARCH

IF4.3

2019-06-24

OAAI

Chen, Kent T. J.; Gilabert-Oriol, Roger; Bally, Marcel B.; Leung, Ada W. Y.

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What Drives Innovation: The Canadian Touch on Liposomal Therapeutics

PHARMACEUTICS

IF5.5

2019-03-16

OAAI

Leung, Ada W. Y.; Amador, Carolyn; Wang, Lin Chuan; Mody, Urmi, V; Bally, Marcel B.

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Copper-CX-5461: A novel liposomal formulation for a small molecule rRNA synthesis inhibitor

JOURNAL OF CONTROLLED RELEASE

IF11.5

2018-09-01

OAAI

Leung, Ada W. Y.; Anantha, Malathi; Dragowska, Wieslawa H.; Wehbe, Mohamed; Bally, Marcel B.

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Transition Metal Ions Promote the Bioavailability of Hydrophobic Therapeutics: Cu and Zn Interactions with RNA PolymeraseI Inhibitor CX5461

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2018-04-10

OAAI

Prosser, Kathleen E.; Leung, Ada W. Y.; Harrypersad, Shane; Lewis, Andrew R.; Bally, Marcel B.; Walsby, Charles J.

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Enhanced Li Storage Stability Induced by Locating Sn in Metal-Organic Frameworks

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2018-04-06

PREAI

Wu, Na; Wang, Wei; Kou, Lu-Qing; Zhang, Xue; Shi, Ya-Ru; Li, Tao-Hai; Li, Feng; Zhou, Jing-Ming; Wei, Yu

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In Vivo Validation ofPAPSS1(3′-phosphoadenosine 5′-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target

CLINICAL CANCER RESEARCH

IF10.2

2017-10-31

OAAI

Leung, Ada W. Y.; Veinotte, Chansey J.; Melong, Nicole; Oh, Min Hee; Chen, Kent; Enfield, Katey S. S.; Backstrom, Ian; Warburton, Corinna; Yapp, Donald; Berman, Jason N.; Bally, Marcel B.; Lockwood, William W.

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Copper (II) complexes of bidentate ligands exhibit potent anti-cancer activity regardless of platinum sensitivity status

INVESTIGATIONAL NEW DRUGS

IF2.7

2017-07-21

OAAI

Wehbe, Mohamed; Lo, Cody; Leung, Ada W. Y.; Dragowska, Wieslawa H.; Ryan, Gemma M.; Bally, Marcel B.

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Development and optimization of an injectable formulation of copper diethyldithiocarbamate, an active anticancer agent

INTERNATIONAL JOURNAL OF NANOMEDICINE

IF6.5

2017-05-01

OAAI

Wehbe, Mohamed; Anantha, Malathi; Shi, Minghan; Leung, Ada Wai-yin; Dragowska, Wieslawa H.; Sanche, Leon; Bally, Marcel B.

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A simple passive equilibration method for loading carboplatin into pre-formed liposomes incubated with ethanol as a temperature dependent permeability enhancer

JOURNAL OF CONTROLLED RELEASE

IF11.5

2017-04-01

OAAI

Wehbe, Moe; Malhotra, Armaan; Anantha, Malathi; Roosendaal, Jeroen; Leung, Ada W. Y.; Plackett, David; Edwards, Katarina; Gilabert-Oriol, Roger; Bally, Marcel B.

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A Perspective - can copper complexes be developed as a novel class of therapeutics?

DALTON TRANSACTIONS

IF3.3

2017-01-01

150

PREAI

Wehbe, Mohamed; Leung, Ada W. Y.; Abrams, Michael J.; Orvig, Chris; Bally, Marcel B.

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Synthetic lethality in lung cancer and translation to clinical therapies

MOLECULAR CANCER

IF33.9

2016-09-29

OAAI

Leung, Ada W. Y.; de Silva, Tanya; Bally, Marcel B.; Lockwood, William W.

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PAPSS1 (3′-phosphoadenosine 5′-phosphosulfate synthase 1) inhibition sensitizes non-small cell lung cancer to cisplatin treatment in vivo

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Leung, Ada W. Y.; Veinotte, Chansey J.; Melong, Nicole; Backstrom, Ian; Warburton, Corinna; Dullaghan, Edie; Berman, Jason N.; Bally, Marcel B.

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A novel injectable formulation of quercetin reliant on the ability of the drug to complex copper

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Chen, Kent T.; Anantha, Malathi; Leung, Ada W. Y.; Wehbe, Mohamed; Sutherland, Brent; Bally, Marcel B.

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A novel formulation of CX-5461, a small-molecule inhibitor of rRNA synthesis, and its use for treatment of acute myeloid leukemia models

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Leung, Ada W. Y.; Anantha, Malathi; Prosser, Kathleen E.; Wehbe, Mohamed; Walsby, Charles J.; Bally, Marcel B.

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Repurposing disulfiram for use as an anticancer drug: a story about metabolism and metal binding

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Wehbe, Moe; Anantha, Malathi; Backstrom, Ian; Leung, Ada; Chen, Kent; Shi, Minghan; Malhotra, Armaan; Edwards, Katarina; Sanche, Leon; Bally, Marcel B.

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Research Directions