P. Michael Conn - Publications, H-index & Citations

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P. Michael Conn

instituto nacional de salud publica

67H-index

350Paper Count

1.4WCitation Count

Published Papers 60

Publication Date

PHARMACOPERONES AS NOVEL THERAPEUTICS FOR DIVERSE PROTEIN CONFORMATIONAL DISEASES

PHYSIOLOGICAL REVIEWS

IF28.7

2018-04-01

OAAI

Tao, Ya-Xiong; Conn, P. Michael

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Receptor antagonism/agonism can be uncoupled from pharmacoperone activity

MOLECULAR AND CELLULAR ENDOCRINOLOGY

IF3.6

2016-10-01

OAAI

Janovick, Jo Ann; Spicer, Timothy P.; Smith, Emery; Bannister, Thomas D.; Kenakin, Terry; Scampavia, Louis; Conn, P. Michael

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Assay strategies for identification of therapeutic leads that target protein trafficking

TRENDS IN PHARMACOLOGICAL SCIENCES

IF19.9

2015-08-01

OAAI

Conn, P. Michael; Spicer, Timothy P.; Scampavia, Louis; Janovick, Jo Ann

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Gonadotrope-specific Deletion of Dicer Results in Severely Suppressed Gonadotropins and Fertility Defects

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-01-01

OAAI

Wang, Huizhen; Graham, Ian; Hastings, Richard; Gunewardena, Sumedha; Brinkmeier, Michelle L.; Conn, P. Michael; Camper, Sally A.; Kumar, T. Rajendra

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Transitioning pharmacoperones to therapeutic use: In vivo proof-of-principle and design of high throughput screens

PHARMACOLOGICAL RESEARCH

IF10.5

2014-05-01

OAAI

Conn, P. Michael; Smithson, David C.; Hodder, Peter S.; Stewart, M. David; Behringer, Richard R.; Smith, Emery; Ulloa-Aguirre, Alfredo; Janovick, Jo Ann

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Pharmacoperone: What's in a word?

PHARMACOLOGICAL RESEARCH

IF10.5

2014-05-01

PREAI

Conn, P. Michael; Ulloa-Aguirre, Alfredo; Janovick, Jo Ann

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Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR

MOLECULAR CELL

IF16.6

2014-04-01

141

OAAI

Houck, Scott A.; Ren, Hong Yu; Madden, Victoria J.; Bonner, Jacob N.; Conlin, Michael P.; Janovick, Jo Ann; Conn, P. Michael; Cyr, Douglas M.

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Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-03-31

OAAI

Wang, Huizhen; Larson, Melissa; Jablonka-Shariff, Albina; Pearl, Christopher A.; Miller, William L.; Conn, P. Michael; Boime, Irving; Kumar, T. Rajendra

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Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function

MOLECULAR AND CELLULAR ENDOCRINOLOGY

IF3.6

2014-01-01

OAAI

Ulloa-Aguirre, Alfredo; Zarinan, Teresa; Dias, James A.; Conn, P. Michael

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Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2013-12-09

OAAI

Janovick, Jo Ann; Stewart, M. David; Jacob, Darla; Martin, L. D.; Deng, Jian Min; Stewart, C. Allison; Wang, Ying; Cornea, Anda; Chavali, Lakshmi; Lopez, Suhujey; Mitalipov, Shoukhrat; Kang, Eunju; Lee, Hyo-Sang; Manna, Pulak R.; Stocco, Douglas M.; Behringer, Richard R.; Conn, P. Michael

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Species sequence differences determine the interaction of GnRH receptor with the cellular quality control system

MOLECULAR AND CELLULAR ENDOCRINOLOGY

IF3.6

2013-12-01

OAAI

Cabrera-Wrooman, Alejandro; Janovick, Jo Ann; Conn, P. Michael

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The Role of Scientists and Clinicians in Raising Public Support for Animal Research in Reproductive Biology and Medicine

BIOLOGY OF REPRODUCTION

IF3

2013-02-01

OAAI

Dancet, E. A. F.; Brannstrom, M.; Brasky, K.; Chai, D.; Chan, A. W. S.; Conn, P. M.; Else, J.; Falconer, H.; Fazleabas, A. T.; Farah, I. O.; Goddeeris, B. M.; Golos, T. G.; Hau, J.; Hearn, J. P.; Kariuki, T. M.; Kyama, C. M.; Lebovic, D. I.; Mwenda, J. M.; Ndung'u, J.; Nyachieo, A.; Parker, J.; Slayden, Ov D.; Stouffer, R. L.; Strauss, J. F.; Taylor, H. S.; Vanderpoel, S.; Westergaard, J. G.; Zelinski, M.; D'Hooghe, T. M.

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Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231

BMC CANCER

IF3.4

2012-11-23

OAAI

Aguilar-Rojas, Arturo; Huerta-Reyes, Maira; Maya-Nunez, Guadalupe; Arechavaleta-Velasco, Fabian; Conn, P. Michael; Ulloa-Aguirre, Alfredo; Valdes, Jesus

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Salt Bridges Overlapping the Gonadotropin-Releasing Hormone Receptor Agonist Binding Site Reveal a Coincidence Detector for G Protein-Coupled Receptor Activation

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2011-08-01

OAAI

Janovick, Jo Ann; Pogozheva, Irina D.; Mosberg, Henry I.; Conn, P. Michael

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Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadism

MOLECULAR AND CELLULAR ENDOCRINOLOGY

IF3.6

2011-04-01

OAAI

Maya-Nunez, Guadalupe; Janovick, Jo Ann; Aguilar-Rojas, Arturo; Jardon-Valadez, Eduardo; Leanos-Miranda, Alfredo; Zarinan, Teresa; Ulloa-Aguirre, Alfredo; Michael Conn, P.

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Dominant negative effects of human follicle-stimulating hormone receptor expression-deficient mutants on wild-type receptor cell surface expression. Rescue of oligomerization-dependent defective receptor expression by using cognate decoys

MOLECULAR AND CELLULAR ENDOCRINOLOGY

IF3.6

2010-06-01

OAAI

Zarinan, Teresa; Perez-Solis, Marco A.; Maya-Nunez, Guadalupe; Casas-Gonzalez, Patricia; Conn, P. Michael; Dias, James A.; Ulloa-Aguirre, Alfredo

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Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs

TRENDS IN ENDOCRINOLOGY AND METABOLISM

IF12.6

2010-03-01

OAAI

Conn, P. Michael; Ulloa-Aguirre, Alfredo

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Salt bridge integrates GPCR activation with protein trafficking

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2010-02-16

OAAI

Janovick, Jo Ann; Conn, P. Michael

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Drug development and the cellular quality control system

TRENDS IN PHARMACOLOGICAL SCIENCES

IF19.9

2009-05-01

PREAI

Conn, P. Michael; Janovick, Jo Ann

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Conformational effects of Lys191 in the human GnRH receptor: mutagenesis and molecular dynamics simulations studies

JOURNAL OF ENDOCRINOLOGY

IF3.9

2009-02-26

OAAI

Jardon-Valadez, Eduardo; Aguilar-Rojas, Arturo; Maya-Nunez, Guadalupe; Leonos-Miranda, Alferdo; Pineiro, Angel; Michael Conn, P.; Ullo-Aguirre, Alfredo

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Research Directions