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S

Sebastian M. Waszak

Cleveland Clinic Foundation

59H-index
369Paper Count
2.6WCitation Count
Published Papers 70
Publication Date
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Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors
errNature Communications
IF15.7
err2025-11-21
err0
errOAAI
errRyan J. Corbett; Rebecca S. Kaufman; Shelly W. McQuaid; Zalman Vaksman; Saksham Phul; Miguel A. Brown; Jennifer L. Mason; Sebastian M. Waszak; Bo Zhang; Chuwei Zhong; Emily Blauel; Heena Desai; Ryan Hausler; Ammar S. Naqvi; Jessica M. Daggett; Alex Sickler; Evan C. Cresswell-Clay; Patricia J. Sullivan; Antonia Chroni; Zhuangzhuang Geng; Elizabeth M. Gonzalez; Yuankun Zhu; Allison P. Heath; Marilyn Li; Phillip B. Storm; Adam C. Resnick; Kara N. Maxwell; Kristina A. Cole; Angela J. Waanders; Miriam Bornhorst; Suzanne P. MacFarland; Jo Lynne Rokita; Sharon J. Diskin
errShare
errSave
ENHANCING GENOME ANALYSIS WITH WHOLE PROTEOME PROFILING FOR IMPROVED THERAPEUTIC DECISION MAKING IN DIFFUSE MIDLINE GLIOMA
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errFindlay, Izac; Staudt, Dilana; Duchatel, Ryan; Jackson, Evangeline; Persson, Mika; McEwen, Holly; Delevaux, Katherine; Smith, Nathan; Vitanza, Nicholas; Cain, Jason; Hansen, Mitchell; Alvaro, Frank; Jakobsen, Lene; Larsen, Martin; Savary, Clara; Waszak, Sebastian; Dun, Matthew
errShare
errSave
EGFR metabolically suppresses differentiation in H3K27M-mutant diffuse midline glioma
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errJi, Sunjong; Doherty, Robert; Mota, Mateus; Natarajan, Siva Kumar; de la Nava, Daniel; Sajjakulnukit, Peter; Peterson, Erik R.; Adam, Tiffany; Niculcea, Michael; Vo, Katie; Wink, Kelsey; Bavani, Subramaniam; Sridevi, Yadavilli; Nazarian, Javad; Phillips, Joanna J.; Mueller, Sabine; Filbin, Mariella; Solomon, David A.; Wahl, Daniel R.; Lyssiotis, Costas; Qin, Tingting; Beck, Alexander; Viswanath, Pavithra; Nuechterlein, Nicholas; Waszak, Sebastian M.; Venneti, Sriram; Koschmann, Carl
errShare
errSave
DISRUPTING INTEGRIN SIGNALING IMPAIRS MIGRATION, MYC-DRIVEN PURINE BIOSYNTHESIS, AND STEMNESS IN H3K27M DIFFUSE MIDLINE GLIOMAS
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errCartaxo, Rodrigo T.; De La Nava, Daniel; Nieblas-Bedolla, Edwin; Niculcea, Michael; Ji, Sunjong; Natarajan, Siva Kumar; Adam, Tiffany; Clausen, Madison; Miclea, Madeline; Siada, Ruby; Schwark, Kallen; Gera, Ananya; Doherty, Robert; Lyssiotis, Costas A.; Favro, Noemi; Covato, Carmelo; Brunschwig, Lucas; Waszak, Sebastian M.; Nuechterlein, Nicholas; Filbin, Mariella; Vo, Tuan; Dun, Matthew D.; Venneti, Sriram; Hara, Toshiro; Koschmann, Carl
errShare
errSave
Effective targeting of EGFR-driven diffuse midline glioma with BLU5082, a novel brain-penetrant EGFR-targeting tyrosine kinase inhibitor (TKI)
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errDoherty, Robert; Wink, Kelsey; Schwark, Kallen; Ji, Sunjong; Gera, Ananya; Messinger, Dana; de la Martin, Daniel Nava; Knowles, Truman; Subramaniam, Bavani; Millet, Yves; Waszak, Sebastian; Phillips, Joanna; Solomon, David; Nazarian, Javad; Mueller, Sabine; Beck, Alexander; Coppe, Jean-Phillipe; Koschmann, Carl
errShare
errSave
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
PREAI
errAhmad, Shiekh Tanveer; Li, Yiran; Garcia-Lopez, Jesus; Gudenas, Brian; Hadley, Jennifer; Paul, Leena; Wu, Stephanie; Refaat, Alaa; Kojic, Marija; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Arnskotter, Frederik; Zindy, Frederique; Jones, Alun; Twarog, Nathaniel; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura; Lu, Meifen; Lewis, Sara; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Shelat, Anang; Waszak, Sebastian; Kutscher, Lena; Lin, Hong; Northcott, Paul
errShare
errSave
Combinatorial targeting of avapritinib-driven MAPK activation in pediatric high-grade glioma
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errSchwark, Kallen; Miclea, Madeline; Patel, Tirth; Kong, Seongbae; Stanczak, Alina; Lau, Benison; Cartaxo, Rodrigo; Messinger, Dana; Doherty, Robert; Ji, Sunjong; Wadden, Jack; Clausen, Madison; Momen, Fareen; Adam, Tiffany; Wink, Kelsey; Hutchinson, Aria; Niculcea, Michael; Serhan, Habib; Merrill, Nathan; Edmonds, Amy; Mayr, Lisa; Neyazi, Sina; Munoz, Denise; Nuechterlein, Nicholas; Fernandez, Ester Calvo; Califano, Andrea; Pavisic, Jovana; Garton, Hugh; Rao, Rama; Upadhyaya, Santhosh; Skrypek, Mary; Bendel, Anne; Lobbous, Mina; Klawinski, Darren; Merajver, Sofia; Koptyra, Mateusz; Resnick, Adam; Nazarian, Javad; Venneti, Sriram; Waszak, Sebastian; Chavez, Lukas; Beck, Alexander; Gojo, Johannes; Filbin, Mariella; Coppe, Jean-Philippe; Koschmann, Carl
errShare
errSave
3D spatial sampling to quantify morphologic heterogeneity in isocitrate dehydrogenase-wildtype glioblastoma
errJOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
IF3
err2025-09-01
err0
errOAAI
errVoong, Viva; Beccari, Sol; Hashemi, Elaheh; Kriener, Birgit; Mathur, Radhika; Lafontaine, Marisa; Shai, Anny; Lupo, Janine M.; Chang, Edward F.; Hervey-Jumper, Shawn L.; Berger, Mitchel S.; Waszak, Sebastian M.; Costello, Joseph F.; Phillips, Joanna J.
errShare
errSave
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target
errCancer Cell
IF44.5
err2025-05-15
err0
errOAAI
errShiekh Tanveer Ahmad; Yiran Li; Jesus Garcia-Lopez; Brian L. Gudenas; Jennifer Hadley; Leena Paul; Stephanie C. Wu; Alaa Refaat; Marija Kojic; Melissa Batts; Taha Soliman; Aaron Pitre; Frederik Arnskötter; Frederique Zindy; Alun Jones; Nathaniel R. Twarog; Anand Mayasundari; Brandon Bianski; Christopher Tinkle; Abbas Shirinifard; Laura Janke; Meifen Lu; Sara A. Lewis; Arzu Onar-Thomas; Stefan M. Pfister; Amar Gajjar; Suzanne J. Baker; Martine F. Roussel; Zoran Rankovic; Giles W. Robinson; Brent A. Orr; Brandon Wainwright; Anang A. Shelat; Sebastian M. Waszak; Lena M. Kutscher; Hong Lin; Paul A. Northcott
errShare
errSave
Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis
errCancer Cell
IF44.5
err2025-05-15
err0
PREAI
errDerek Dang; Akash Deogharkar; John McKolay; Kyle S. Smith; Pooja Panwalkar; Simon Hoffman; Wentao Tian; Sunjong Ji; Ana P. Azambuja; Siva Kumar Natarajan; Joanna Lum; Jill Bayliss; Katie Manzeck; Stefan R. Sweha; Erin Hamanishi; Matthew Pun; Diya Patel; Sagar Rau; Olamide Animasahun; Abhinav Achreja; Martin P. Ogrodzinski; Jutta Diessl; Jennifer Cotter; Debra Hawes; Fusheng Yang; Robert Doherty; Andrea T. Franson; Allison R. Hanaford; Charles G. Eberhart; Eric H. Raabe; Brent A. Orr; Robert J. Wechsler-Reya; Brandon Chen; Costas A. Lyssiotis; Yatrik M. Shah; Sophia Y. Lunt; Ruma Banerjee; Alexander R. Judkins; John R. Prensner; Carl Koschmann; Sebastian M. Waszak; Deepak Nagrath; Marcos Simoes-Costa; Paul A. Northcott; Sriram Venneti
errShare
errSave
Germline analysis of an international cohort of pediatric diffuse midline glioma patients
errNEURO-ONCOLOGY
IF13.4
err2025-03-12
err0
PREAI
errMarion K Mateos; Pamela Ajuyah; Noemi Fuentes-Bolanos; Sam El-Kamand; Paulette Barahona; Ann-Kristin Altekoester; Chelsea Mayoh; Holly Holliday; Jie Liu; Louise Cui; Elke Pfaff; Alan Mackay; Adam C Resnick; Mark Pinese; Loretta M S Lau; Dong-Anh Khuong-Quang; Kimberly Dias; Catherine Goudie; Alison Salkeld; Jo Lynne Rokita; David T W Jones; Nikoleta Juretic; Elisha Hayden; Stefan M Pfister; Christof M Kramm; Mirjam Blattner-Johnson; Nada Jabado; Maria Tsoli; Orazio Vittorio; Sabine Mueller; Yiran Guo; Katherine Tucker; Sebastian M Waszak; Sebastien Perreault; Chris Jones; Marie Wong-Erasmus; Mark J Cowley; David S Ziegler
errShare
errSave
Genetic ancestry superpopulations show distinct prevalence and outcomes across pediatric central nervous system tumors from the Pediatric Brain Tumor Atlas and Pediatric Neuro-Oncology Consortium
errNEURO-ONCOLOGY
IF13.4
err2025-01-23
err0
PREAI
errCorbett, Ryan J.; Gullickson, Cricket C.; Geng, Zhuangzhuang; Brown, Miguel A.; Zhang, Bo; Zhong, Chuwei; Van Kuren, Nicholas; Chroni, Antonia; Blackden, Christopher; Naqvi, Ammar S.; Plisiewicz, Alexa; Mchugh, Sean; Drake, Emmett; Lehmann, Kaitlin; Davidson, Tom B.; Prados, Michael; Storm, Phillip B.; Resnick, Adam C.; Waanders, Angela J.; Waszak, Sebastian M.; Mueller, Sabine; Rokita, Jo Lynne; Kline, Cassie
errShare
errSave
Germline loss-of-function variant in the E3 ubiquitin ligase TRAF2 in a young adult patient with medulloblastoma: a case report
errACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
err2024-12-20
err0
errOAAI
errVo, Josh N.; Franson, Andrea; Waszak, Sebastian M.; Wu, Yi-Mi; Becker, Nicole; Chinnaiyan, Arul M.; Robinson, Dan R.
errShare
errSave
GERMLINEELP1 DEFICIENCY SENSITIZES CEREBELLAR GRANULE NEURON PROGENITORS TO SHH MEDULLOBLASTOMA
errNEURO-ONCOLOGY
IF13.4
err2024-11-11
err0
PREAI
errTanveer Ahmad, Shiekh; Garcia-Lopez, Jesus; Li, Yiran; Hadley, Jennifer; Paul, Leena; Gudenas, Brian; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Kojic, Marija; Manz, Frederik; Zindy, Frederique; Jones, Alun; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura Janke; Lu, Meifen; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Kutscher, Lena; Waszak, Sebastian; Lin, Hong; Northcott, Paul
errShare
errSave
PNOC008: A PILOT TRIAL TESTING THE CLINICAL BENEFIT OF USING MOLECULAR PROFILING TO DETERMINE AN INDIVIDUALIZED TREATMENT PLAN IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMA (EXCLUDING DIFFUSE INTRINSIC PONTINE GLIOMA)
errNEURO-ONCOLOGY
IF13.4
err2024-11-11
err0
PREAI
errKilburn, Lindsay; Franson, Andrea; Cooney, Tab; Kline, Cassie; Stoller, Schuyler; Reddy, Alyssa; Banerjee, Anu; Packer, Roger; Bendel, Anne; Skrypek, Maggie; Minturn, Jane; Abdelbaki, Mohamed; Whipple, Nicholas; Chan, Priya; Crawford, John; Crotty, Erin; Waanders, Angela; Elster, Jennifer; Raabe, Eric; George, Elizabeth; Pinto, Soniya; Supakul, Nucharin; Kraya, Adam; Prados, Michael; Nazarian, Javad; Solomon, David; Long-Boyle, Janel; Molinaro, Annette; Waszak, Sebastian; Mueller, Sabine
errShare
errSave
Somatic CpG hypermutation is associated with mismatch repair deficiency in cancer
errMOLECULAR SYSTEMS BIOLOGY
IF7.7
err2024-07-18
err0
errOAAI
errFlynn, Aidan; Waszak, Sebastian M.; Weischenfeldt, Joachim
errShare
errSave
PNOC008: A PILOT TRIAL TESTING THE CLINICAL BENEFIT OF USING MOLECULAR PROFILING TO DETERMINE AN INDIVIDUALIZED TREATMENT PLAN IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMA (EXCLUDING DIFFUSE INTRINSIC PONTINE GLIOMA)
errNEURO-ONCOLOGY
IF13.4
err2024-06-18
err0
errOAAI
errFranson, Andrea T.; Kilburn, Lindsay B.; Cooney, Tab M.; Stoller, Schuyler; Reddy, Alyssa T.; Banerjee, Anu; Packer, Roger J.; Bendel, Anne E.; Skrypek, Mary M.; Minturn, Jane E.; Abdelbaki, Mohamed S.; Whipple, Nicholas S.; Chan, Priya; Crawford, John R.; Crotty, Erin E.; Waanders, Angela J.; Elster, Jennifer D.; Raabe, Eric H.; George, Elizabeth; Pinto, Soniya N.; Vossough, Arastoo; Kraya, Adam A.; Prados, Michael; Kline, Cassie; Nazarian, Javad; Solomon, David A.; Long-Boyle, Janel R.; Molinaro, Annette M.; Waszak, Sebastian M.; Mueller, Sabine
errShare
errSave
PEDIATRIC PATIENTS WITH DIFFUSE MIDLINE GLIOMA DEMONSTRATE AN UNEXPECTED PREVALENCE OF GERMLINE VARIANTS IN HOMOLOGOUS RECOMBINATION GENES
errNEURO-ONCOLOGY
IF13.4
err2024-06-18
err0
errOAAI
errMateos, Marion K.; Ajuyah, Pamela; Fuentes-Bolanos, Noemi; El Kamand, Sam; Barahona, Paulette; Altekoester, Ann; Mayoh, Chelsea; Holiday, Holly; Liu, Jie; Cui, Louise; Pfaff, Elke; Mackay, Alan; Resnick, Adam; Pinese, Mark; Lau, Loretta M. S.; Khuong-Quang, Dong-Anh; Dias, Kimberly; Goudie, Catherine; Salkeld, Alison; Rokita, Jo Lynne; Jones, David T. W.; Juretic, Nikoleta; Hayden, Elisha; Pfister, Stefan M.; Kramm, Christof M.; Blattner-Johnson, Mirjam; Jabado, Nada; Tsoli, Maria; Vittorio, Orazio; Mueller, Sabine; Guo, Yiran; Tucker, Katherine; Waszak, Sebastian M.; Perreault, Sebastien; Jones, Chris; Wong-Erasmus, Marie; Cowley, Mark J.; Ziegler, David S.
errShare
errSave
GERMLINEELP1 DEFICIENCY SENSITIZES CEREBELLAR GRANULE NEURON PROGENITORS TO SHH MEDULLOBLASTOMA
errNEURO-ONCOLOGY
IF13.4
err2024-06-18
err0
errOAAI
errAhmad, Shiekh Tanveer; Garcia-Lopez, Jesus; Li, Yiran; Gudenas, Brian; Hadley, Jennifer; Paul, Leena; Batts, Melissa; Soliman, Taha; Kojic, Marija; Pitre, Aaron; Manz, Frederik; Zindy, Frederique; Jones, Alun; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura; Lu, Meifen; Pfister, Stefan M.; Gajjar, Amar; Baker, Suzanne J.; Roussel, Martine F.; Rankovic, Zoran; Waszak, Sebastian M.; Robinson, Giles W.; Orr, Brent A.; Wainwright, Brandon; Kutscher, Lena M.; Lin, Hong; Northcott, Paul A.
errShare
errSave
PNOC022 REPORT: A COMBINATION THERAPY TRIAL USING AN ADAPTIVE PLATFORM DESIGN FOR PATIENTS WITH DIFFUSE MIDLINE GLIOMA AT INITIAL DIAGNOSIS, POST-RADIATION THERAPY, OR PROGRESSION
errNEURO-ONCOLOGY
IF13.4
err2024-06-18
err0
errOAAI
errKline, Cassie; Franson, Andrea; Banerjee, Anuradha; Reddy, Alyssa T.; Raber, Shannon; Hoffman, Carly; Minturn, Jane; van der Lugt, Jasper; de Vos-Kerkhof, Evelien; van Vuurden, Dannis; Gerber, Nicolas; Stucklin, Ana S. Guerreiro; Kilburn, Lindsay; Elster, Jennifer; Whipple, Nicholas; Cohen, Kenneth; Oren, Michal Yalon; Gardner, Sharon; Cluster, Andrew; Chi, Susan; Landi, Daniel; McCowage, Geoffrey; Vo, Josh; Resnick, Adam; Phillips, Joanna; Bhatia, Aashim; George, Elizabeth; Vossough, Arastoo; Nabavizadeh, Ali; Braunstein, Steve; Gupta, Nalin; Prados, Michael; Waszak, Sebastian; Long-Boyle, Janel; Molinaro, Annette; Dun, Matthew; Koschmann, Carl; Nazarian, Javad; Mueller, Sabine
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
G
Gad Getz
H-index: 248 · Papers: 1.8K
H
Hermann Brenner
H-index: 202 · Papers: 3.3K
M
Mark Gerstein
H-index: 191 · Papers: 1.2K
A
Andreas von Deimling
H-index: 175 · Papers: 1.8K
P
Paul Flicek
H-index: 167 · Papers: 522
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