Tim Zacharewski - Publications, H-index & Citations

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Tim Zacharewski

michigan state university

36H-index

106Paper Count

6.0KCitation Count

Published Papers 28

Publication Date

Loss of Dioxin Response Element-Mediated Induction of PKM2 Reprograms Hepatic Metabolism in Response to TCDD

International Journal of Molecular Sciences 2025, Vol. 26, Page 10853

IF4.9

2025-11-08

OAAI

Karina Orlowska; Rance Nault; Tim Zacharewski

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Cell-specific AHR-driven differential gene expression in the mouse liver cell following acute TCDD exposure

BMC GENOMICS

IF3.7

2024-08-28

OAAI

Cholico, Giovan N.; Nault, Rance; Zacharewski, Tim

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Inhibition of the urea cycle by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum ammonia levels in mice

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-01-01

OAAI

Cholico, Giovan N.; Fling, Russell R.; Sink, Warren J.; Nault, Rance; Zacharewski, Tim

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Generative modeling of single-cell gene expression for dose-dependent chemical perturbations

PATTERNS

IF7.4

2023-08-01

OAAI

Kana, Omar; Nault, Rance; Filipovic, David; Marri, Daniel; Zacharewski, Tim; Bhattacharya, Sudin

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A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data

ENVIRONMENTAL HEALTH PERSPECTIVES

IF9.8

2023-06-01

OAAI

Nault, Rance; Cave, Matthew C.; Ludewig, Gabriele; Moseley, Hunter N. B.; Pennell, Kelly G.; Zacharewski, Tim

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Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver

SCIENTIFIC REPORTS

IF3.9

2023-03-13

OAAI

Cholico, Giovan N.; Orlowska, Karina; Fling, Russell R.; Sink, Warren J.; Zacharewski, Nicholas A.; Fader, Kelly A.; Nault, Rance; Zacharewski, Tim

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A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds

TOXICS

IF4.1

2022-11-17

OAAI

Liu, Rongrui; Zacharewski, Tim R.; Conolly, Rory B.; Zhang, Qiang

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Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice

TOXICOLOGICAL SCIENCES

IF4.1

2022-10-12

OAAI

Nault, Rance; Saha, Satabdi; Bhattacharya, Sudin; Sinha, Samiran; Maiti, Tapabrata; Zacharewski, Tim

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Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the β-oxidation-like pathway resulting in acrylyl-CoA conjugate buildup

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-09-01

OAAI

Orlowska, Karina; Fling, Russ R.; Nault, Rance; Sink, Warren J.; Schilmiller, Anthony L.; Zacharewski, Tim

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Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose-response study designs

NUCLEIC ACIDS RESEARCH

IF13.1

2022-01-21

OAAI

Nault, Rance; Saha, Satabdi; Bhattacharya, Sudin; Dodson, Jack; Sinha, Samiran; Maiti, Tapabrata; Zacharewski, Tim

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Genetics-Based Approach to Identify Novel Genes Regulated by the Aryl Hydrocarbon Receptor in Mouse Liver

TOXICOLOGICAL SCIENCES

IF4.1

2021-03-15

OAAI

Jurgelewicz, Amanda; Dornbos, Peter; Warren, Melanie; Nault, Rance; Arkatkar, Anooj; Lin, Hui; Threadgill, David W.; Zacharewski, Tim; LaPres, John J.

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Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

IF7.4

2021-01-01

OAAI

Nault, Rance; Fader, Kelly A.; Bhattacharya, Sudin; Zacharewski, Tim R.

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice

SCIENTIFIC REPORTS

IF3.9

2020-09-09

OAAI

Fling, Russell R.; Doskey, Claire M.; Fader, Kelly A.; Nault, Rance; Zacharewski, Tim R.

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2020-07-01

OAAI

Doskey, Claire M.; Fader, Kelly A.; Nault, Rance; Lydic, Todd; Matthews, Jason; Potter, Dave; Sharratt, Bonnie; Williams, Kurt; Zacharewski, Tim

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A toxicogenomic approach for the risk assessment of the food contaminant acetamide

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2020-02-01

OAAI

Nault, Rance; Bals, Bryan; Teymouri, Farzaneh; Black, Michael B.; Andersen, Melvin E.; McMullen, Patrick D.; Krishnan, Seetha; Kuravadi, Nagesh; Paul, Neetha; Kumar, Santhosh; Kannan, Kamala; Jayachandra, K. C.; Alagappan, Lakshmanan; Patel, Bhavesh Dhirajlal; Bogen, Kenneth T.; Gollapudi, Bhaskar B.; Klaunig, James E.; Zacharewski, Tim R.; Bringi, Venkataraman

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Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction

MOLECULAR PHARMACOLOGY

IF3

2018-08-01

OAAI

Nault, Rance; Doskey, Claire M.; Fader, Kelly A.; Rockwell, Cheryl E.; Zacharewski, Tim

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Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity (vol 321, pg 1, 2017)

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2018-04-01

OAAI

Fader, K. A.; Nault, R.; Kirby, M. P.; Markous, G.; Matthews, J.; Zacharewski, T. R.

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Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis

TOXICOLOGICAL SCIENCES

IF4.1

2016-08-25

OAAI

Nault, Rance; Fader, Kelly A.; Ammendolia, Dustin A.; Dornbos, Peter; Potter, Dave; Sharratt, Bonnie; Kumagai, Kazuyoshi; Harkema, Jack R.; Lunt, Sophia Y.; Matthews, Jason; Zacharewski, Tim

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RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice

BMC GENOMICS

IF3.7

2015-05-10

OAAI

Nault, Rance; Fader, Kelly A.; Zacharewski, Tim

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Automated Dose-Response Analysis of the Relative Hepatic Gene Expression Potency of TCDF in C57BL/6 Mice

TOXICOLOGICAL SCIENCES

IF4.1

2009-08-12

PREAI

Burgoon, Lyle D.; Ding, Qi; N'jai, Alhaji; Dere, Ed; Burg, Ashley R.; Rowlands, J. Craig; Budinsky, Robert A.; Stebbins, Kenneth E.; Zacharewski, Tim R.

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Research Directions