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K

Karen L. Mohlke

university of north carolina at chapel hill

113H-index
572Paper Count
8.0WCitation Count
Published Papers 186
Publication Date
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Cross-ancestry comparison of aptamer and antibody protein measures
errNature Communications
IF15.7
err2026-01-22
err0
errOAAI
errJayna C. Nicholas; Daniel H. Katz; Usman A. Tahir; Catherine L. Debban; Francois Aguet; Thomas Blackwell; Russell P. Bowler; K. Alaine Broadaway; Jingsha Chen; Clary B. Clish; Josef Coresh; Elaine Cornell; Daniel E. Cruz; Rajat Deo; Margaret F. Doyle; Peter Durda; Lynette Ekunwe; James S. Floyd; Dipender Gill; Xiuqing Guo; Ron C. Hoogeveen; Craig Johnson; Leslie A. Lange; Yun Li; Alisa Manning; James B. Meigs; Michael Y. Mi; Josyf C. Mychaleckyj; Nels C. Olson; Katherine A. Pratte; Brucy M. Psaty; Alexander P. Reiner; Peifeng Ruan; Magdalena Sevilla-Gonzalez; Amil M. Shah; Quan Sun; Russell P. Tracy; Jia Wen; Alexis C. Wood; James G. Wilson; Kristin L. Young; Bing Yu; Mary R. Rooney; Ani Manichaikul; Ruth Dubin; Karen L. Mohlke; Stephen S. Rich; Jerome I. Rotter; Peter Ganz; Robert E. Gerszten; Kent D. Taylor; Laura M. Raffield
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Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits
errThe American Journal of Human Genetics
IF0
err2025-12-02
err0
errOAAI
errAbdalla A. Alkhawaja; Kevin W. Currin; Hannah J. Perrin; Swarooparani Vadlamudi; Amy S. Etheridge; K. Alaine Broadaway; Gabrielle H. Cannon; Carlton W. Anderson; Anne H. Moxley; Alina C. Iuga; Erin G. Schuetz; Federico Innocenti; Terrence S. Furey; Karen L. Mohlke
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errSave
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations
errNature Communications
IF15.7
err2025-10-01
err0
errOAAI
errBoya Guo; Yanwei Cai; Daeeun Kim; Roelof A. J. Smit; Zhe Wang; Kruthika R. Iyer; Austin T. Hilliard; Jeffrey Haessler; Ran Tao; K. Alaine Broadaway; Yujie Wang; Nikita Pozdeyev; Frederik F. Stæger; Chaojie Yang; Brett Vanderwerff; Amit D. Patki; Lauren Stalbow; Meng Lin; Nicholas Rafaels; Jonathan Shortt; Laura Wiley; Maggie Stanislawski; Jack Pattee; Lea Davis; Peter S. Straub; Megan M. Shuey; Nancy J. Cox; Nanette R. Lee; Marit E. Jørgensen; Peter Bjerregaard; Christina Larsen; Torben Hansen; Ida Moltke; James B. Meigs; Daniel O. Stram; Xianyong Yin; Xiang Zhou; Kyong-Mi Chang; Shoa L. Clarke; Rodrigo Guarischi-Sousa; Joanna Lankester; Philip S. Tsao; Steven Buyske; Mariaelisa Graff; Laura M. Raffield; Quan Sun; Lynne R. Wilkens; Christopher S. Carlson; Charles B. Easton; Simin Liu; JoAnn E. Manson; Loïc L. Marchand; Christopher A. Haiman; Karen L. Mohlke; Penny Gordon-Larsen; Anders Albrechtsen; Michael Boehnke; Stephen S. Rich; Ani Manichaikul; Jerome I. Rotter; Noha A. Yousri; Ryan M. Irvin; Chris Gignoux; Kari E. North; Ruth J. F. Loos; Themistocles L. Assimes; Ulrike Peters; Charles Kooperberg; Sridharan Raghavan; Heather M. Highland; Burcu F. Darst
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errSave
Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci
errInternational Journal of Obesity
IF3.8
err2025-09-26
err0
errOAAI
errHanfei Xu; Shreyash Gupta; Ian Dinsmore; Abbey Kollu; Anne Marie Cawley; Mohammad Y. Anwar; Hung-Hsin Chen; Lauren E. Petty; Sudha Seshadri; Misa Graff; Jennifer E. Below; Jennifer A. Brody; Geetha Chittoor; Susan P. Fisher-Hoch; Nancy L. Heard-Costa; Daniel Levy; Honghuang Lin; Ruth J. F. Loos; Joseph B. Mccormick; Jerome I. Rotter; Tooraj Mirshahi; Christopher D. Still; Anita Destefano; L. Adrienne Cupples; Karen L. Mohlke; Kari E. North; Anne E. Justice; Ching-Ti Liu
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errSave
Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits
errThe American Journal of Human Genetics
IF0
err2025-09-23
err0
errOAAI
errEmma P. Wilson; K. Alaine Broadaway; Victoria A. Parsons; Swarooparani Vadlamudi; Narisu Narisu; Sarah M. Brotman; Kevin W. Currin; Heather M. Stringham; Michael R. Erdos; Ryan Welch; Jeffrey K. Holtzman; Timo A. Lakka; Markku Laakso; Jaakko Tuomilehto; Michael Boehnke; Heikki A. Koistinen; Francis S. Collins; Stephen C.J. Parker; Laura J. Scott; Karen L. Mohlke
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errSave
Genomic loci and molecular genetic mechanisms for hidradenitis suppurativa
errBRITISH JOURNAL OF DERMATOLOGY
IF9.6
err2025-09-01
err2
errOAAI
errBroadaway, K. Alaine; Sun, Quan; Edmiston, Sharon N.; Currin, Kevin W.; Vadlamudi, Swarooparani; Miller-Fleming, Tyne W.; Shi, Yue; Fajgenbaum, Kristen; Melendez-Gonzalez, Maria; Bui, Helen; Blum, Franklin R.; Westerkam, Linnea; Shams, Rayad; Mallela, Teja; Levitt, Brandt; Lin, Lan; Hao, Honglin; Memili, Aylin; Straub, Peter; Zhou, Wei; Harris, Kathleen Mullan; Martin, Alicia; Cox, Nancy J.; Liu, Zhi; Thomas, Nancy E.; Li, Yun; Mohlke, Karen L.; Sayed, Christopher J.
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Extensive differential gene expression and regulation by sex in human skeletal muscle
errCell Genomics
IF9
err2025-06-05
err0
errOAAI
errSarah C. Hanks; Abigail S. Mauger; Arushi Varshney; Dan L. Ciotlos; Nandini Manickam; Narisu Narisu; Alexandria J. Shumway; Peter Orchard; Michael R. Erdos; Michael D. Sweeney; Jeffrey Okamoto; Anne U. Jackson; Heather M. Stringham; Lori L. Bonnycastle; Xiang Zhou; Timo A. Lakka; Karen L. Mohlke; Jaakko Tuomilehto; Markku Laakso; Michael Boehnke; Praveen Sethupathy; Francis S. Collins; Heikki A. Koistinen; Stephen C.J. Parker; Laura J. Scott
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errSave
Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2024-09-01
err1
PREAI
errBroadaway, K. Alaine; Brotman, Sarah M.; Rosen, Jonathan D.; Currin, Kevin W.; Alkhawaja, Abdalla A.; Etheridge, Amy S.; Wright, Fred; Gallins, Paul; Jima, Dereje; Zhou, Yi-hui; Love, Michael I.; Innocenti, Federico; Mohlke, Karen L.
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errSave
ADA Presidents' Select Abstract: Discovering Stimulatory State-Specific Type 2 Diabetes GWAS Mechanisms with Single-Cell Multiomics on iPSC-Derived Fibro-adipogenic Progenitor Cell Villages
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errVentresca, Christa; Varshney, Arushi; Orchard, Peter; Tsan, Yao-Chang; Da Rocha, Andre Monteiro; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Herron, Todd J.; Bielas, Stephanie; Parker, Stephen
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errSave
Population-Scale Skeletal Muscle Single-Nucleus Multiomic Profiling Reveals Extensive Context-Specific Genetic Regulation
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errVarshney, Arushi; Manickam, Nandini; Orchard, Peter; Tovar, Adelaide; Zhang, Zhenhao; Feng, Fan; Lakka, Timo A.; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Mohlke, Karen L.; Kitzman, Jacob; Koistinen, Heikki A.; Liu, Jie; Boehnke, Michael; Collins, Francis S.; Scott, Laura; Parker, Stephen C.
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errSave
Widespread Age-Associated Changes in the Chromatin Architecture of Skeletal Muscle Cell Types
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errMoo, Keagan G.; Albanus, Ricardo D'Oliveira; Varshney, Arushi; Orchard, Peter; Manickam, Nandini; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Parker, Stephen
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errSave
Liver regulatory mechanisms of noncoding variants at lipid and metabolic trait loci
errHUMAN GENETICS AND GENOMICS ADVANCES
IF3.6
err2024-04-01
err3
errOAAI
errPandey, Gautam K.; Vadlamudi, Swarooparani; Currin, Kevin W.; Moxley, Anne H.; Nicholas, Jayna C.; Mcafee, Jessica C.; Broadaway, K. Alaine; Mohlke, Karen L.
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errSave
Pla2g12b drives expansion of triglyceride-rich lipoproteins (vol 15, 2095, 2024)
errNATURE COMMUNICATIONS
IF15.7
err2024-03-22
err0
errOAAI
errThierer, James H.; Foresti, Ombretta; Yadav, Pradeep Kumar; Wilson, Meredith H.; Moll, Tabea O. C.; Shen, Meng-Chieh; Busch-Nentwich, Elisabeth M.; Morash, Margaret; Mohlke, Karen L.; Rawls, John F.; Malhotra, Vivek; Hussain, M. Mahmood; Farber, Steven A.
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errSave
Pla2g12b drives expansion of triglyceride-rich lipoproteins
errNATURE COMMUNICATIONS
IF15.7
err2024-03-07
err8
errOAAI
errThierer, James H.; Foresti, Ombretta; Yadav, Pradeep Kumar; Wilson, Meredith H.; Moll, Tabea O. C.; Shen, Meng-Chieh; Busch-Nentwich, Elisabeth M.; Morash, Margaret; Mohlke, Karen L.; Rawls, John F.; Malhotra, Vivek; Hussain, M. Mahmood; Farber, Steven A.
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errSave
Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing
errCRISPR JOURNAL
IF4
err2024-02-01
err2
errOAAI
errBonnycastle, Lori L.; Swift, Amy J.; Mansell, Erin C.; Lee, Angela; Winnicki, Elizabeth; Li, Elizabeth S.; Robertson, Catherine C.; Parsons, Victoria A.; Huynh, Trung; Krilow, Chad; Mohlke, Karen L.; Erdos, Michael R.; Narisu, Narisu; Collins, Francis S.
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errSave
Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
errGENOME BIOLOGY
IF9.4
err2024-01-16
err4
errOAAI
errBradfield, Jonathan P.; Kember, Rachel L.; Ulrich, Anna; Balkiyarova, Zhanna; Alyass, Akram; Aris, Izzuddin M.; Bell, Joshua A.; Broadaway, K. Alaine; Chen, Zhanghua; Chai, Jin-Fang; Davies, Neil M.; Fernandez-Orth, Dietmar; Bustamante, Mariona; Fore, Ruby; Ganguli, Amitavo; Heiskala, Anni; Hottenga, Jouke-Jan; Iniguez, Carmen; Kobes, Sayuko; Leinonen, Jaakko; Lowry, Estelle; Lyytikainen, Leo-Pekka; Mahajan, Anubha; Pitkanen, Niina; Schnurr, Theresia M.; Have, Christian Theil; Strachan, David P.; Thiering, Elisabeth; Vogelezang, Suzanne; Wade, Kaitlin H.; Wang, Carol A.; Wong, Andrew; Holm, Louise Aas; Chesi, Alessandra; Choong, Catherine; Cruz, Miguel; Elliott, Paul; Franks, Steve; Frithioff-Bojsoe, Christine; Gauderman, W. James; Glessner, Joseph T.; Gilsanz, Vicente; Griesman, Kendra; Hanson, Robert L.; Kaakinen, Marika; Kalkwarf, Heidi; Kelly, Andrea; Kindler, Joseph; Kahonen, Mika; Lanca, Carla; Lappe, Joan; Lee, Nanette R.; McCormack, Shana; Mentch, Frank D.; Mitchell, Jonathan A.; Mononen, Nina; Niinikoski, Harri; Oken, Emily; Pahkala, Katja; Sim, Xueling; Teo, Yik-Ying; Baier, Leslie J.; van Beijsterveldt, Toos; Adair, Linda S.; Boomsma, Dorret, I; de Geus, Eco; Guxens, Monica; Eriksson, Johan G.; Felix, Janine F.; Gilliland, Frank D.; Biobank, Penn Medicine; Hansen, Torben; Hardy, Rebecca; Hivert, Marie-France; Holm, Jens-Christian; Jaddoe, Vincent W. V.; Jarvelin, Marjo-Riitta; Lehtimaki, Terho; Mackey, David A.; Meyre, David; Mohlke, Karen L.; Mykkanen, Juha; Oberfield, Sharon; Pennell, Craig E.; Perry, John R. B.; Raitakari, Olli; Rivadeneira, Fernando; Saw, Seang-Mei; Sebert, Sylvain; Shepherd, John A.; Standl, Marie; Sorensen, Thorkild I. A.; Timpson, Nicholas J.; Torrent, Maties; Willemsen, Gonneke; Hypponen, Elina; Power, Chris; McCarthy, Mark, I; Freathy, Rachel M.; Widen, Elisabeth; Hakonarson, Hakon; Prokopenko, Inga; Voight, Benjamin F.; Zemel, Babette S.; Grant, Struan F. A.; Cousminer, Diana L.
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errSave
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
errNATURE GENETICS
IF31.8
err2023-09-07
err20
errOAAI
errLagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; Gonzalez, Karla Sofia Gutierrez; Balkhiyarova, Zhanna; Faggian, Alessia; Maina, Jared G.; Chen, Shiqian; Todorov, Petar V.; Sharapov, Sodbo; David, Alessia; Marullo, Letizia; Magi, Reedik; Rujan, Roxana-Maria; Ahlqvist, Emma; Thorleifsson, Gudmar; Gao, He; Evangelou, Evangelos; Benyamin, Beben; Scott, Robert A.; Isaacs, Aaron; Zhao, Jing Hua; Willems, Sara M.; Johnson, Toby; Gieger, Christian; Grallert, Harald; Meisinger, Christa; Mueller-Nurasyid, Martina; Strawbridge, Rona J.; Goel, Anuj; Rybin, Denis; Albrecht, Eva; Jackson, Anne U.; Stringham, Heather M.; Correa, Ivan R., Jr.; Farber-Eger, Eric; Steinthorsdottir, Valgerdur; Uitterlinden, Andre G.; Munroe, Patricia B.; Brown, Morris J.; Schmidberger, Julian; Holmen, Oddgeir; Thorand, Barbara; Hveem, Kristian; Wilsgaard, Tom; Mohlke, Karen L.; Wang, Zhe; Shmeliov, Aleksey; den Hoed, Marcel; Loos, Ruth J. F.; Kratzer, Wolfgang; Haenle, Mark; Koenig, Wolfgang; Boehm, Bernhard O.; Tan, Tricia M.; Tomas, Alejandra; Salem, Victoria; Barroso, Ines; Tuomilehto, Jaakko; Boehnke, Michael; Florez, Jose C.; Hamsten, Anders; Watkins, Hugh; Njolstad, Inger; Wichmann, H. -Erich; Caulfield, Mark J.; Khaw, Kay-Tee; van Duijn, Cornelia M.; Hofman, Albert; Wareham, Nicholas J.; Langenberg, Claudia; Whitfield, John B.; Martin, Nicholas G.; Montgomery, Grant; Scapoli, Chiara; Tzoulaki, Ioanna; Elliott, Paul; Thorsteinsdottir, Unnur; Stefansson, Kari; Brittain, Evan L.; McCarthy, Mark I.; Froguel, Philippe; Sexton, Patrick M.; Wootten, Denise; Groop, Leif; Dupuis, Josee; Meigs, James B.; Deganutti, Giuseppe; Demirkan, Ayse; Pers, Tune H.; Reynolds, Christopher A.; Aulchenko, Yurii S.; Kaakinen, Marika A.; Jones, Ben; Prokopenko, Inga
errShare
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Genetic Variants Associated With Hidradenitis Suppurativa
errJAMA DERMATOLOGY
IF11
err2023-09-01
err19
errOAAI
errSun, Quan; Broadaway, K. Alaine; Edmiston, Sharon N.; Fajgenbaum, Kristen; Miller-Fleming, Tyne; Westerkam, Linnea Lackstrom; Melendez-Gonzalez, Maria; Bui, Helen; Blum, Franklin R.; Levitt, Brandt; Lin, Lan; Hao, Honglin; Harris, Kathleen Mullan; Liu, Zhi; Thomas, Nancy E.; Cox, Nancy J.; Li, Yun; Mohlke, Karen L.; Sayed, Christopher J.
errShare
errSave
Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits
errDIABETES
IF7.5
err2023-08-30
err4
errOAAI
errBrotman, Sarah M.; Oravilahti, Anniina; Rosen, Jonathan D.; Alvarez, Marcus; Heinonen, Sini; van der Kolk, Birgitta W.; Silva, Lilian Fernandes; Perrin, Hannah J.; Vadlamudi, Swarooparani; Pylant, Cortney; Deochand, Sonia; Basta, Patricia V.; Valone, Jordan M.; Narain, Morgan N.; Stringham, Heather M.; Boehnke, Michael; Kuusisto, Johanna; Love, Michael I.; Pietilainen, Kirsi H.; Pajukanta, Paivi; Laakso, Markku; Mohlke, Karen L.
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Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
errNATURE GENETICS
IF31.8
err2023-06-08
err18
errOAAI
errWilliamson, Alice; Norris, Dougall M.; Yin, Xianyong; Broadaway, K. Alaine; Moxley, Anne H.; Vadlamudi, Swarooparani; Wilson, Emma P.; Jackson, Anne U.; Ahuja, Vasudha; Andersen, Mette K.; Arzumanyan, Zorayr; Bonnycastle, Lori L.; Bornstein, Stefan R.; Bretschneider, Maxi P.; Buchanan, Thomas A.; Chang, Yi-Cheng; Chuang, Lee-Ming; Chung, Ren-Hua; Clausen, Tine D.; Damm, Peter; Delgado, Graciela E.; de Mello, Vanessa D.; Dupuis, Josee; Dwivedi, Om P.; Erdos, Michael R.; Silva, Lilian Fernandes; Frayling, Timothy M.; Gieger, Christian; Goodarzi, Mark O.; Guo, Xiuqing; Gustafsson, Stefan; Hakaste, Liisa; Hammar, Ulf; Hatem, Gad; Herrmann, Sandra; Hojlund, Kurt; Horn, Katrin; Hsueh, Willa A.; Hung, Yi-Jen; Hwu, Chii-Min; Jonsson, Anna; Karhus, Line L.; Kleber, Marcus E.; Kovacs, Peter; Lakka, Timo A.; Lauzon, Marie; Lee, I-Te; Lindgren, Cecilia M.; Lindstrom, Jaana; Linneberg, Allan; Liu, Ching-Ti; Luan, Jian'an; Aly, Dina Mansour; Mathiesen, Elisabeth; Moissl, Angela P.; Morris, Andrew P.; Narisu, Narisu; Perakakis, Nikolaos; Peters, Annette; Prasad, Rashmi B.; Rodionov, Roman N.; Roll, Kathryn; Rundsten, Carsten F.; Sarnowski, Chloe; Savonen, Kai; Scholz, Markus; Sharma, Sapna; Stinson, Sara E.; Suleman, Sufyan; Tan, Jingyi; Taylor, Kent D.; Uusitupa, Matti; Vistisen, Dorte; Witte, Daniel R.; Walther, Romy; Wu, Peitao; Xiang, Anny H.; Zethelius, Bjorn; Ahlqvist, Emma; Bergman, Richard N.; Chen, Yii-Der Ida; Collins, Francis S.; Fall, Tove; Florez, Jose C.; Fritsche, Andreas; Grallert, Harald; Groop, Leif; Hansen, Torben; Koistinen, Heikki A.; Komulainen, Pirjo; Laakso, Markku; Lind, Lars; Loeffler, Markus; Maerz, Winfried; Meigs, James B.; Raffel, Leslie J.; Rauramaa, Rainer; Rotter, Jerome I.; Schwarz, Peter E. H.; Stumvoll, Michael; Sundstrom, Johan; Toenjes, Anke; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Wagner, Robert; Barroso, Ines; Walker, Mark; Grarup, Niels; Boehnke, Michael; Wareham, Nicholas J.; Mohlke, Karen L.; Wheeler, Eleanor; O'Rahilly, Stephen; Fazakerley, Daniel J.; Langenberg, Claudia
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Research Directions

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Co-authors
Cooperation Journals
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