Not logged in THY1: A Therapeutically Targetable Mediator of Treatment Resistance in H3K27M Pediatric Tumors Syed, Safiulla; Tripathy, Arushi; Ji, Sunjong; Alomary, Yazen; de la Nava Martin, Dani; Mota, Mateus; Chakravarthy, Reka; Huang, Dah-Luen; Wang, Zhuwen; Li, Zian; Zhang, Qiang; Lawrence, Theodore; Wahl, Daniel; Koschmann, Carl; Venneti, Sriram; Rehemtulla, Alnawaz; Al-Holou, Wajd Share Save
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Leveraging the immunomodulatory effects of dordaviprone (ONC201) to induce long-term survival response in diffuse midline glioma patients and models Savary, Clara; Persson, Mika L.; Jackson, Evangeline R.; Duchatel, Ryan J.; Vo, Tuan; Findlay, Izac J.; Douglas, Alicia M.; Bramberger, Liesl; De La Nava, Daniel; Thomas, Bryce C.; Mcewen, Holly P.; Beitaki, Tyrone S.; De La Fuente, Laura Rodriguez; Colino-Sanguino, Yolanda; Mora, Fatima Valdes; Larsen, Martin R.; Faridi, Pouya; Holst, Jeff; Mayall, Jemma; Kline, Cassie N.; Franson, Andrea T.; Venneti, Sriram; Hondermarck, Hubert; Horvat, Jay; Nixon, Brett; Cartaxo, Rodrigo; Nazarian, Javad; Hulleman, Esther; Mueller, Sabine; Vitanza, Nicholas A.; Koschmann, Carl; Alonso, Marta M.; Carvalheiro, Tiago Ferreira; Van Der Lugt, Jasper; Dun, Matthew D. Share Save
EGFR metabolically suppresses differentiation in H3K27M-mutant diffuse midline glioma Ji, Sunjong; Doherty, Robert; Mota, Mateus; Natarajan, Siva Kumar; de la Nava, Daniel; Sajjakulnukit, Peter; Peterson, Erik R.; Adam, Tiffany; Niculcea, Michael; Vo, Katie; Wink, Kelsey; Bavani, Subramaniam; Sridevi, Yadavilli; Nazarian, Javad; Phillips, Joanna J.; Mueller, Sabine; Filbin, Mariella; Solomon, David A.; Wahl, Daniel R.; Lyssiotis, Costas; Qin, Tingting; Beck, Alexander; Viswanath, Pavithra; Nuechterlein, Nicholas; Waszak, Sebastian M.; Venneti, Sriram; Koschmann, Carl Share Save
PRECISION ONCOLOGY FOR HIGH-GRADE GLIOMAS: A TUMOR ORGANOID PLATFORM FOR RAPID, PATIENT-SPECIFIC DRUG SCREENING Tripathy, Arushi; Ji, Sunjong; Alomary, Yazen; Raghunathan, Reka Chakravarthy; Syed, Safiulla; Ravikumar, Visweswaran; Shankar, Sunita; Serhan, Habib; Huang, Dah-Luen; Hara, Toshiro; Clarke, Nathan; Koschmann, Carl; Merrill, Nathan; Merajver, Sofia; Al-Holou, Wajd Share Save
ZFTA-RELA ependymomas produce macrophage-associated itaconate as an oncometabolite to epigenetically sustain pathogenic fusion expression Natarajan, Siva Kumar; Lum, Joanna; Haggerty-Skeans, James; Nenwani, Minal; Eyunni, Sanjana; Mota, Mateus; Bayliss, Jill; Deogharkar, Akash; Hamanishi, Erin; Hoffman, Simon; Young, Eleanor; Zhang, Qiuyang; Mehta, Rijul; Parolia, Abhijit; Sajjakulnukit, Peter; Doherty, Robert; Koschmann, Carl; Chinnaiyan, Arul; Lyssiotis, Costas; Nagrath, Deepak; Venneti, Sriram Share Save
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Patient-derived tumor-oids recapitulate the tumor microenvironment and allow for pre-clinical drug screening across the entire spectrum of pediatric brain tumors Wink, Kelsey; Adam, Tiffany; Serhan, Habib; Beale, David R.; Beck, Maxwell; Wadden, Jack; Gehrand, Ashley; Prensner, John; Upadhyaya, Santhosh; Franson, Andrea; Chen, Kevin; Marupudi, Neena; Garton, Hugh; Magge, Suresh N.; Al-Holou, Wajd; Venneti, Sriram; Mody, Rajen; Chinnaiyan, Arul; Rood, Brian R.; Nazarian, Javad; Mueller, Sabine; Mitra, Siddhartha; Green, Adam L.; Kraya, Adam; Merrill, Nathan; Merajver, Sofia D.; Resnick, Adam; Koptyra, Mateus; Koschmann, Carl Share Save
LEVETIRACETAM THERAPEUTICALLY TARGETS GABAERGIC SYNAPSES IN DIFFUSE MIDLINE GLIOMA Barron, Tara; Yalcin, Belgin; Su, Minhui; Mochizuki, Aaron; Drexler, Richard; Cantor, Evan; Byun, Youkyeong Gloria; Gavish, Avishai; Shamardani, Kiarash; Xu, Haojun; Ni, Lijun; Soni, Neeraj; Tlais, Dana; Franson, Andrea; Lyons, Samantha; Mehta, Vilina; Kim, Yoon Seok; Taylor, Kathryn R.; Quezada, Michael A.; Keough, Michael B.; Jahan, Samin Malaki; Geraghty, Anna C.; Mancusi, Rebecca; Vo, Linh Thuy; Casteneda, Enrique Herrera; Woo, Pamelyn J.; Ricklefs, Franz L.; Schuller, Ulrich; Petritsch, Claudia K.; Vogel, Hannes; Fisher, Paul G.; Campen, Cynthia J.; Partap, Sonia; Kaila, Kai; Koschmann, Carl; Monje, Michelle Share Save
DISRUPTING INTEGRIN SIGNALING IMPAIRS MIGRATION, MYC-DRIVEN PURINE BIOSYNTHESIS, AND STEMNESS IN H3K27M DIFFUSE MIDLINE GLIOMAS Cartaxo, Rodrigo T.; De La Nava, Daniel; Nieblas-Bedolla, Edwin; Niculcea, Michael; Ji, Sunjong; Natarajan, Siva Kumar; Adam, Tiffany; Clausen, Madison; Miclea, Madeline; Siada, Ruby; Schwark, Kallen; Gera, Ananya; Doherty, Robert; Lyssiotis, Costas A.; Favro, Noemi; Covato, Carmelo; Brunschwig, Lucas; Waszak, Sebastian M.; Nuechterlein, Nicholas; Filbin, Mariella; Vo, Tuan; Dun, Matthew D.; Venneti, Sriram; Hara, Toshiro; Koschmann, Carl Share Save
Effective targeting of EGFR-driven diffuse midline glioma with BLU5082, a novel brain-penetrant EGFR-targeting tyrosine kinase inhibitor (TKI) Doherty, Robert; Wink, Kelsey; Schwark, Kallen; Ji, Sunjong; Gera, Ananya; Messinger, Dana; de la Martin, Daniel Nava; Knowles, Truman; Subramaniam, Bavani; Millet, Yves; Waszak, Sebastian; Phillips, Joanna; Solomon, David; Nazarian, Javad; Mueller, Sabine; Beck, Alexander; Coppe, Jean-Phillipe; Koschmann, Carl Share Save
THY1 Mediates Treatment Resistance in H3K7M Pediatric Tumors and is Therapeutically Targetable Syed, Safiulla; Ji, Sunjong; Tripathy, Arushi; Alomary, Yazen; Chakravarthy, Reka; Mota, Mateus; Huang, Dah-Luen; Wang, Zhuwen; Li, Zian; Zhang, Qiang; de la Martin, Daniel Nava; Lawrence, Theodore; Wahl, Daniel; Koschmann, Carl; Venneti, Sriram; Rehemtulla, Alnawaz; Al-Holou, Wajd Share Save
ATRX LOSS LEADS TO H3K4ME3-DRIVEN EPIGENETIC DYSREGULATION OF OLIGODENDROCYTE DIFFERENTIATION AND CELL CYCLE CONTROL IN H3K27M-MUTANT DIFFUSE MIDLINE GLIOMA (DMG) Messinger, Dana; Patel, Jina; Doherty, Robert; De La Nava, Daniel; Clausen, Madison; Schwark, Kallen; Stanczak, Alina; Momen, Fareen; Kuchinski, Kennedy; Parsels, Leslie A.; Parsels, Joshua D.; Ji, Sunjong; Mota, Mateus; Venneti, Sriram; Zhang, Qiang; Morgan, Meredith; Qin, Tingting; Yadav, Viveka Nand; Koschmann, Carl Share Save
Combinatorial targeting of avapritinib-driven MAPK activation in pediatric high-grade glioma Schwark, Kallen; Miclea, Madeline; Patel, Tirth; Kong, Seongbae; Stanczak, Alina; Lau, Benison; Cartaxo, Rodrigo; Messinger, Dana; Doherty, Robert; Ji, Sunjong; Wadden, Jack; Clausen, Madison; Momen, Fareen; Adam, Tiffany; Wink, Kelsey; Hutchinson, Aria; Niculcea, Michael; Serhan, Habib; Merrill, Nathan; Edmonds, Amy; Mayr, Lisa; Neyazi, Sina; Munoz, Denise; Nuechterlein, Nicholas; Fernandez, Ester Calvo; Califano, Andrea; Pavisic, Jovana; Garton, Hugh; Rao, Rama; Upadhyaya, Santhosh; Skrypek, Mary; Bendel, Anne; Lobbous, Mina; Klawinski, Darren; Merajver, Sofia; Koptyra, Mateusz; Resnick, Adam; Nazarian, Javad; Venneti, Sriram; Waszak, Sebastian; Chavez, Lukas; Beck, Alexander; Gojo, Johannes; Filbin, Mariella; Coppe, Jean-Philippe; Koschmann, Carl Share Save
Tail ligation recombinase polymerase amplification sequencing (TLDRseq) enables sensitive, same-day, multi-gene sequencing for plasma-based detection and timely monitoring of brain tumor ctDNA Wadden, Jack; Aittaleb, Rayan; Adam, Tiffany; Jackson, Conner; John, Vishal; Lau, Benison; Calvert, Rebecca; Franson, Andrea; Mody, Rajen; Prensner, John; Upadhyaya, Santhosh; Koschmann, Carl Share Save
Precision Targeting of PI3K/mTOR in Diffuse Midline Glioma: GCT007 as a Novel Brain-Penetrant PIK3CA Inhibitor Jackson, Evangeline; Duchatel, Ryan; Vo, Tuan; Savary, Clara; Germon, Zacary; Riley, Madisen; McEwen, Holly; Persson, Mika; Findlay, Izac; Beitaki, Tyrone; Lally, Marissa; Douglas, Alicia; Rogers, M. Karen Newell; Fonkem, Ekokobe; Franson, Andrea; Kline, Cassie; Nazarian, Javad; Koschmann, Carl; Mueller, Sabine; Dun, Matthew Share Save
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H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition Guo, Yupei; Li, Zian; Parsels, Leslie A.; Wang, Zhuwen; Parsels, Joshua D.; Dalvi, Anushka; The, Stephanie; Hu, Nan; Valvo, Victoria M.; Doherty, Robert; Peterson, Erik; Wang, Xinjun; Venkataraman, Sujatha; Agnihotri, Sameer; Venneti, Sriram; Wahl, Daniel R.; Green, Michael D.; Lawrence, Theodore S.; Koschmann, Carl; Morgan, Meredith A.; Zhang, Qiang Share Save
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