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Douglas J. Winton

university of cambridge

45H-index
129Paper Count
9.3KCitation Count
Published Papers 52
Publication Date
Paired mutation calling and spatial transcriptomics identify cellular neighborhoods associated with the neoplastic outcome of mouse colitis
err2026-07-28
err0
errOAAI
errElisa B. Moutin; Linus L. H. Chang; Giada Giavara; Shenay Mehmed; Mathilde Colombé; Carla Boquetale; Kate Marks; Filipe C. Lourenço; Nefeli Skoufou-Papoutsaki; Richard Kemp; Philippe Gascard; Thea D. Tlsty; David S. Tourigny; Douglas J. Winton
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Clonal biases dictate availability of colonic cancer driver mutations for transformation
err2026-04-16
err0
errOAAI
errNefeli Skoufou-Papoutsaki; Richard Kemp; Sam Adler; Kate Marks; Anne-Claire Girard; Shenay Mehmed; Filipe C. Lourenço; Elisa B. Moutin; Rogier Ten Hoopen; Edward Morrissey; Douglas J. Winton; David S. Tourigny
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Decay of driver mutations shapes the landscape of intestinal transformation
errNature
IF48.5
err2025-12-03
err0
errOAAI
errFilipe C. Lourenço; Iannish D. Sadien; Kim Wong; Sam Adler; Ashley Sawle; Leonor Schubert Santana; Lee Hazelwood; Giada Giavara; Anna M. Nicholson; Matthew D. Eldridge; Noori Maka; Gerard Lynch; Stephen T. McSorley; Joanne Edwards; Richard Kemp; David J. Adams; Douglas J. Winton
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Extracellular Matrix Orchestration of Tissue Remodeling in the Chronically Inflamed Mouse Colon
err2024-01-01
err3
errOAAI
errMoutin, Elisa B.; Bons, Joanna; Giavara, Giada; Lourenco, Filipe; Pan, Deng; Burton, Jordan B.; Shah, Samah; Colombe, Mathilde; Gascard, Philippe; Tlsty, Thea; Schilling, Birgit; Winton, Douglas J.
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Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPR
err2023-10-05
err7
errOAAI
errSkoufou-Papoutsaki, Nefeli; Adler, Sam; D'Santos, Paula; Mannion, Liz; Mehmed, Shenay; Kemp, Richard; Smith, Amy; Perrone, Francesca; Nayak, Komal; Russell, Alasdair; Zilbauer, Matthias; Winton, Douglas J.
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Cross talk between Paneth and tuft cells drives dysbiosis and inflammation in the gut mucosa
err2023-06-12
err15
errOAAI
errCoutry, Nathalie; Nguyen, Julie; Soualhi, Salima; Gerbe, Francois; Meslier, Victoria; Dardalhon, Valerie; Almeida, Mathieu; Quinquis, Benoit; Thirion, Florence; Herbert, Fabien; Gasmi, Imene; Lamrani, Ali; Giordano, Alicia; Cesses, Pierre; Garnier, Laure; Thirard, Steeve; Greuet, Denis; Cazevieille, Chantal; Bernex, Florence; Bressuire, Christelle; Winton, Douglas; Matsumoto, Ichiro; And, Herve M. Naomi; Taylor, Naomi; Jay, Philippe
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The NALCN channel regulates metastasis and nonmalignant cell dissemination
err2023-01-15
err0
PREAI
errRahrmann, Eric; Shorthouse, David; Jassim, Amir; Hu, Linda; Ortiz, Mariaestela; Mahler-Araujo, Betania; Vogel, Peter; Paez-Ribes, Marta; Fatemi, Atefeh; Hannon, Gregory; Iyer, Radhika; Blundon, Jay; Lourenco, Filipe; Kay, Jonathan; Nazarian, Rosaylnn; Hall, Benjamin; Zakharenko, Stanislav; Winton, Douglas; Zhu, Liqin; Gilbertson, Richard
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The NALCN channel regulates metastasis and nonmalignant cell dissemination
err2022-09-29
err37
errOAAI
errRahrmann, Eric P.; Shorthouse, David; Jassim, Amir; Hu, Linda P.; Ortiz, Mariaestela; Mahler-Araujo, Betania; Vogel, Peter; Paez-Ribes, Marta; Fatemi, Atefeh; Hannon, Gregory J.; Iyer, Radhika; Blundon, Jay A.; Lourenco, Filipe C.; Kay, Jonathan; Nazarian, Rosalynn M.; Hall, Benjamin A.; Zakharenko, Stanislav S.; Winton, Douglas J.; Zhu, Liqin; Gilbertson, Richard J.
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Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas
err2021-11-01
err11
errOAAI
errLodestijn, Sophie C.; van den Bosch, Tom; Nijman, Lisanne E.; Moreno, Leandro F.; Schlingemann, Sophie; Sheraton, Vivek M.; van Neerven, Sanne M.; Koning, Jasper J.; Braga, Felipe A. Vieira; Paauw, Nanne J.; Lecca, Maria C.; Lenos, Kristiaan J.; Morrissey, Edward; Miedema, Daniel M.; Winton, Douglas J.; Bijlsma, Maarten F.; Vermeulen, Louis
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A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium
err2021-08-01
err7
errOAAI
errOlpe, Cora; Khamis, Doran; Chukanova, Maria; Skoufou-Papoutsaki, Nefeli; Kemp, Richard; Marks, Kate; Tatton, Cerys; Lindskog, Cecilia; Nicholson, Anna; Brunton-Sim, Roxanne; Malhotra, Shalini; ten Hoopen, Rogier; Stanley, Rachael; Winton, Douglas J.; Morrissey, Edward
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Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration
err2021-07-01
err26
errOAAI
errKoppens, Martijn A. J.; Davis, Hayley; Valbuena, Gabriel N.; Mulholland, Eoghan J.; Nasreddin, Nadia; Colombe, Mathilde; Antanaviciute, Agne; Biswas, Sujata; Friedrich, Matthias; Lee, Lennard; Wang, Lai Mun; Koelzer, Viktor H.; East, James E.; Simmons, Alison; Winton, Douglas J.; Leedham, Simon J.
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5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation
err2020-01-17
err21
errOAAI
errUribe-Lewis, Santiago; Carroll, Thomas; Menon, Suraj; Nicholson, Anna; Manasterski, Piotr J.; Winton, Douglas J.; Buczacki, Simon J. A.; Murrell, Adele
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Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing
err2020-01-01
err3
errOAAI
errThorsen, Ann-Sofie; Khamis, Doran; Kemp, Richard; Colombe, Mathilde; Lourenco, Filipe C.; Morrissey, Edward; Winton, Douglas
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Quantifying Microsatellite Mutation Rates from Intestinal Stem Cell Dynamics in Msh2-Deficient Murine Epithelium
err2019-05-24
err5
errOAAI
errChristopher, Joseph; Thorsen, Ann-Sofie; Abujudeh, Sam; Lourenco, Filipe C.; Kemp, Richard; Potter, Paul K.; Morrissey, Edward; Hazelwood, Lee; Winton, Douglas J.
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Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts
err2019-03-08
err52
errOAAI
errvan der Heijden, Maartje; Miedema, Daniel M.; Waclaw, Bartlomiej; Veenstra, Veronique L.; Lecca, Maria C.; Nijman, Lisanne E.; van Dijk, Erik; van Neerven, Sanne M.; Lodestijn, Sophie C.; Lenos, Kristiaan J.; de Groot, Nina E.; Prasetyanti, Pramudita R.; Varea, Andrea Arricibita; Winton, Douglas J.; Medema, Jan Paul; Morrissey, Edward; Ylstra, Bauke; Nowak, Martin A.; Bijlsma, Maarten F.; Vermeulen, Louis
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Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models
err2019-02-13
err32
errOAAI
errMieszczanek, Juliusz; van Tienen, Laurens M.; Ibrahim, Ashraf E. K.; Winton, Douglas J.; Bienz, Mariann
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Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer
err2018-09-03
err132
errOAAI
errLenos, Kristiaan J.; Miedema, Daniel M.; Lodestijn, Sophie C.; Nijman, Lisanne E.; van den Bosch, Tom; Ros, Xavier Romero; Lourenco, Filipe C.; Lecca, Maria C.; van der Heijden, Maartje; van Neerven, Sanne M.; van Oort, Anita; Leveille, Nicolas; Adam, Ronja S.; Melo, Felipe de Sousa E.; Otten, Joy; Veerman, Patrick; Hypolite, Guillaume; Koens, Lianne; Lyons, Scott K.; Stassi, Giorgio; Winton, Douglas J.; Medema, Jan Paul; Morrissey, Edward; Bijlsma, Maarten F.; Vermeulen, Louis
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Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration
err2018-09-01
err70
errOAAI
errTomic, Goran; Morrissey, Edward; Kozar, Sarah; Ben-Moshe, Shani; Hoyle, Alice; Azzarelli, Roberta; Kemp, Richard; Chilamakuri, Chandra Sekhar Reddy; Itzkovitz, Shalev; Philpott, Anna; Winton, Douglas J.
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Itraconazole targets cell cycle heterogeneity in colorectal cancer
err2018-05-31
err53
errOAAI
errBuczacki, Simon J. A.; Popova, Semiramis; Biggs, Emma; Koukorava, Chrysa; Buzzelli, Jon; Vermeulen, Louis; Hazelwood, Lee; Francies, Hayley; Garnett, Mathew J.; Winton, Douglas J.
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Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells
err2018-03-19
err70
errOAAI
errHuels, D. J.; Bruens, L.; Hodder, M. C.; Cammareri, P.; Campbell, A. D.; Ridgway, R. A.; Gay, D. M.; Solar-Abboud, M.; Faller, W. J.; Nixon, C.; Zeiger, L. B.; McLaughlin, M. E.; Morrissey, E.; Winton, D. J.; Snippert, H. J.; van Rheenen, J.; Sansom, O. J.
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