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Alexander Hoffmann

and institute for quantitative and computational biosciences

80H-index
273Paper Count
2.4WCitation Count
Published Papers 128
Publication Date
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Macrophage response specificity to ligand mixtures is improved by signaling pathway antagonism
errMolecular Systems Biology
IF7.7
err2026-07-29
err0
errOAAI
errXiaolu Guo; Supriya Sen; Julian Gonzalez; Alexander Hoffmann
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Phased fragility and stability of non-genetic B cell states in the germinal center accelerate the genetic evolution of antibodies
errCell Systems
IF7.7
err2026-04-20
err0
errOAAI
errMark Y. Xiang; Haripriya Vaidehi Narayanan; Vaibhava Kesarwani; Rohan Vanheusden; Tiffany Wang; Alexander Hoffmann
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A data-driven model of macrophage polarization states reveals an IFN macrophage signature in active Crohn’s disease
errFrontiers in Immunology
IF5.9
err2025-12-04
err0
errOAAI
errSarina C. Lowe†; Madelaine Leitman†; Noah Yan; Alexander Hoffmann
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errSave
Topological measures on phylogenetic trees of the antibody repertoire reveal the underlying kinetics of B cell fate decisions
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errNarayanan, Haripriya Vaidehi; Li, Chengyuan; Liu, Jianche; Xiang, Mark Y.; Huang, Helen; Hoffmann, Alexander
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Macrophage reprogramming regulated by temporal and combinatorial signaling codes
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errHoffmann, Alexander
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errSave
Distinct roles for NF-κB in hematopoietic stem cells and the bone marrow milieu in promoting hematopoietic aging
errCell Reports
IF6.9
err2025-08-26
err0
PREAI
errJennifer J. Chia; Apeksha Singh; Yu-Sheng Lin; Noa Popko; David Mastro; Yi Liu; Tiffany Tran; Jennifer K. King; Dinesh S. Rao; Alexander Hoffmann
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Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL
errCell Death & Disease
IF9.6
err2025-08-16
err0
errOAAI
errAimilia Vareli; Haripriya Vaidehi Narayanan; Heather Clark; Eleanor Jayawant; Hui Zhou; Yi Liu; Emma Kennedy; Lauren Stott; Fabio Simoes; Alexander Hoffmann; Andrea Pepper; Chris Pepper; Simon Mitchell
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errSave
NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promoters
errCELL DISCOVERY
IF12.5
err2025-02-11
err2
errOAAI
errNavarro, Hector I.; Daly, Allison E.; Rodriguez, Benancio; Wu, Sunny; Ngo, Kim A.; Fraser, Anna; Schiffman, Allison; Liu, Yi; Smale, Stephen T.; Chia, Jennifer J.; Hoffmann, Alexander
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Single-cell stimulus-response gene expression trajectories reveal the stimulus specificities of dynamic responses by single macrophages
errMOLECULAR CELL
IF16.6
err2024-11-01
err0
errOAAI
errSheu, Katherine M.; Pimplaskar, Aditya; Hoffmann, Alexander
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Dynamical and combinatorial coding by MAPK p38 and NFκB in the inflammatory response of macrophages
errMOLECULAR SYSTEMS BIOLOGY
IF7.7
err2024-06-13
err0
errOAAI
errLuecke, Stefanie; Guo, Xiaolu; Sheu, Katherine M.; Singh, Apeksha; Lowe, Sarina C.; Han, Minhao; Diaz, Jessica; Lopes, Francisco; Wollman, Roy; Hoffmann, Alexander
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errSave
Co-imaging of RelA and c-Rel reveals features of NF- K B signaling for ligand discrimination
errCELL REPORTS
IF6.9
err2024-03-01
err2
errOAAI
errRahman, Shah Md Toufiqur; Singh, Apeksha; Lowe, Sarina; Aqdas, Mohammad; Jiang, Kevin; Narayanan, Haripriya Vaidehi; Hoffmann, Alexander; Sung, Myong-Hee
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errSave
Tracking of lineage mass via quantitative phase imaging and confinement in low refractive index microwells
errLAB ON A CHIP
IF5.4
err2024-01-01
err0
PREAI
errZhang, Jingzhou; Griffin, Justin; Roy, Koushik; Hoffmann, Alexander; Zangle, Thomas A.
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errSave
Use of Transcriptional Signatures to Differentiate Pathogen-Specific and Treatment-Specific Host Responses in Patients With Bacterial Bloodstream Infections
errJOURNAL OF INFECTIOUS DISEASES
IF4.5
err2023-11-24
err2
PREAI
errThaden, Joshua T.; Ahn, Richard; Ruffin, Felicia; Gjertson, David W.; Hoffmann, Alexander; Fowler, Vance G.; Yeaman, Michael R.
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errSave
RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is interferon-independent
errJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
IF11.2
err2023-11-01
err4
errOAAI
errNavarro, Hector I.; Liu, Yi; Fraser, Anna; Lefaudeux, Diane; Chia, Jennifer J.; Vong, Linda; Roifman, Chaim M.; Hoffmann, Alexander
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errSave
Tonic TNF conditioning of macrophages safeguards stimulus-specific inflammatory responses
errEMBO REPORTS
IF6.2
err2023-05-22
err3
errOAAI
errLuecke, Stefanie; Adelaja, Adewunmi; Guo, Xiaolu; Sen, Supriya; Spreafico, Roberto; Singh, Apeksha; Liu, Yi; Taylor, Brooks; Diaz, Jessica; Cheng, Quen; Hoffmann, Alexander
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errSave
NFicB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity
errJOURNAL OF AUTOIMMUNITY
IF7
err2023-05-01
err7
errOAAI
errSharfe, Nigel; Dalal, Ilan; Naghdi, Zahra; Lefaudeux, Diane; Vong, Linda; Dadi, Harjit; Navarro, Hector; Tasher, Diana; Ovadia, Adi; Zangen, Tzili; Ater, Dorit; Ngan, Bo; Hoffmann, Alexander; Roifman, Chaim M.
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errSave
Nuclear localization of IκBα is mediated by the second ankyrin repeat:: the IκBα ankyrin repeats define a novel class of cis-acting nuclear import sequences
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err148
errOAAI
errSachdev, S; Hoffmann, A; Hannink, M
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Generation and activation of multiple dimeric transcription factors within the NF-κB signaling system
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err134
errOAAI
errBasak, Soumen; Shih, Vincent Feng-Sheng; Hoffmann, Alexander
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A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes
errMOLECULAR SYSTEMS BIOLOGY
IF7.7
err2023-03-17
err5
errOAAI
errWilder, Catera L.; Lefaudeux, Diane; Mathenge, Raisa; Kishimoto, Kensei; Munoz, Alma Zuniga; Nguyen, Minh A.; Meyer, Aaron S.; Cheng, Quen J.; Hoffmann, Alexander
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The NF-?B multidimer system model: A knowledge base to explore diverse biological contexts
errSCIENCE SIGNALING
IF6.6
err2023-03-14
err12
errOAAI
errMitchell, Simon; Tsui, Rachel; Tan, Zhixin Cyrillus; Pack, Arran; Hoffmann, Alexander
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Research Directions

No research directions
Co-authors
Cooperation Journals
M
Michael Karin
H-index: 254 · Papers: 902
D
David Baltimore
H-index: 209 · Papers: 1.1K
C
Christopher K. Glass
H-index: 170 · Papers: 569
M
Michael G. Rosenfeld
H-index: 169 · Papers: 491
L
Lewis L. Lanier
H-index: 165 · Papers: 709
View more