Christopher C.W. Hughes - Publications, H-index & Citations

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Christopher C.W. Hughes

university of california-irvine

63H-index

213Paper Count

1.9WCitation Count

Published Papers 87

Publication Date

A microphysiological system HHT-on-a-chip platform recapitulates patient vascular lesions

Nature Communications

IF15.7

2026-08-13

OAAI

Jennifer S. Fang; Christopher J. Hatch; Jillian Andrejecsk; William Van Trigt; Joshua R. Gonzales; Damie J. Juat; Edward K. Looker; Sophia R. Harris; Yu-Hsi Chen; Satomi Matsumoto; Abraham P. Lee; Christopher C. W. Hughes

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ImmuniT Platform for Improved Neoantigen Prediction in Lung Cancer

Vaccines 2025, Vol. 13, Page 921

IF3.4

2025-08-29

OAAI

Stephanie J. Hachey; Alexander G. Forsythe; Hari B. Keshava; Christopher C. W. Hughes

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A vascular-associated fibroblastic cell controls pancreatic islet immunity

Cell Reports

IF6.9

2025-08-28

PREAI

Don Clarke; Anne Costanzo; Siddhartha Sharma; Lisa Kain; Kelley W. Moremen; Jeremy Pettus; Alain Domissy; Peng Wu; Kim-Vy Nguyen-Ngoc; Denise Berti; Steven C. George; Christopher C.W. Hughes; Maike Sander; Luc Teyton

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Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

Developmental Cell

IF8.7

2025-05-23

OAAI

Yesl Jun; Kim-Vy Nguyen-Ngoc; Somesh Sai; R. Hugh F. Bender; Winnie Gong; Vira Kravets; Han Zhu; Christopher J. Hatch; Michael Schlichting; Roberto Gaetani; Medhavi Mallick; Stephanie J. Hachey; Karen L. Christman; Steven C. George; Christopher C.W. Hughes; Maike Sander

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Fundamental considerations for designing endothelialized in vitro models of thrombosis

THROMBOSIS RESEARCH

IF3.4

2024-04-01

OAAI

Lemmens, Titus P.; Broker, Vanessa; Rijpkema, Minke; Hughes, Christopher C. W.; Schurgers, Leon J.; Cosemans, Judith M. E. M.

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Single-cell transcriptomic analysis of partial endothelial-to-mesenchymal transition in sprouting angiogenesis

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Thapa, Kapil; Hatch, Christopher J.; Hughes, Christopher; Fang, Jennifer S.

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A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction

BIOFABRICATION

IF8

2024-01-11

OAAI

Bender, R. Hugh F.; ODonnell, Benjamen T.; Shergill, Bhupinder; Pham, Brittany Q.; Tahmouresie, Sima; Sanchez, Celeste N.; Juat, Damie J.; Hatch, Michaela M. S.; Shirure, Venktesh S.; Wortham, Matthew; Nguyen-Ngoc, Kim-Vy; Jun, Yesl; Gaetani, Roberto; Christman, Karen L.; Teyton, Luc; George, Steven C.; Sander, Maike; Hughes, Christopher C. W.

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Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model

BREAST CANCER RESEARCH

IF5.6

2024-01-05

OAAI

Hachey, Stephanie J.; Hatch, Christopher J.; Gaebler, Daniela; Mocherla, Aneela; Nee, Kevin; Kessenbrock, Kai; Hughes, Christopher C. W.

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A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease

TRANSLATIONAL RESEARCH

IF5.9

2023-05-01

OAAI

Hachey, Stephanie J.; Sobrino, Agua; Lee, John G.; Jafari, Mehraneh D.; Klempner, Samuel J.; Puttock, Eric J.; Edwards, Robert A.; Lowengrub, John S.; Waterman, Marian L.; Zell, Jason A.; Hughes, Christopher C. W.

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ASO Visual Abstract: Plasma Exosome Gene Signature Differentiates Colon Cancer from Healthy Controls

ANNALS OF SURGICAL ONCOLOGY

IF3.5

2023-03-16

PREAI

Vallejos, Paul A. A.; Gonda, Amber; Yu, Jingjing; Sullivan, Brittany G.; Ostowari, Arsha; Kwong, Mei Li; Choi, Audrey; Selleck, Matthew J. J.; Kabagwira, Janviere; Fuller, Ryan N. N.; Gironda, Daniel J. J.; Levine, Edward A. A.; Hughes, Christopher C. W.; Wall, Nathan R. R.; Miller, Lance D. D.; Senthil, Maheswari

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Plasma Exosome Gene Signature Differentiates Colon Cancer from Healthy Controls

ANNALS OF SURGICAL ONCOLOGY

IF3.5

2023-03-02

OAAI

Vallejos, Paul A. A.; Gonda, Amber; Yu, Jingjing; Sullivan, Brittany G. G.; Ostowari, Arsha; Kwong, Mei Li; Choi, Audrey; Selleck, Matthew J. J.; Kabagwira, Janviere; Fuller, Ryan N. N.; Gironda, Daniel J. J.; Levine, Edward A. A.; Hughes, Christopher C. W.; Wall, Nathan R. R.; Miller, Lance D. D.; Senthil, Maheswari

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Organotypic stromal cells impact endothelial cell transcriptome in 3D microvessel networks

SCIENTIFIC REPORTS

IF3.9

2022-11-28

OAAI

Curtis, Matthew B.; Kelly, Natalie; Hughes, Christopher C. W.; George, Steven C.

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Deconstructing Allograft Adipose and Fascia Matrix: Fascia Matrix Improves Angiogenesis, Volume Retention, and Adipogenesis in a Rodent Model

PLASTIC AND RECONSTRUCTIVE SURGERY

IF3.4

2022-10-11

OAAI

Ziegler, Mary E.; Sorensen, Alexandria M.; Banyard, Derek A.; Sayadi, Lohrasb R.; Chnari, Evangelia; Hatch, Michaela M.; Tassey, Jade; Mirzakhanyan, Yeva; Gershon, Paul D.; Hughes, Christopher C. W.; Evans, Gregory R. D.; Widgerow, Alan D.

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Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer

CELL REPORTS

IF6.9

2022-04-01

OAAI

Jahid, Sohail; Ortega, Jose A.; Vuong, Linh M.; Acquistapace, Isabella Maria; Hachey, Stephanie J.; Flesher, Jessica L.; La Serra, Maria Antonietta; Brindani, Nicoletta; La Sala, Giuseppina; Manigrasso, Jacopo; Arencibia, Jose M.; Bertozzi, Sine Mandrup; Summa, Maria; Bertorelli, Rosalia; Armirotti, Andrea; Jin, Rongsheng; Liu, Zheng; Chen, Chi-Fen; Edwards, Robert; Hughes, Christopher C. W.; De Vivo, Marco; Ganesan, Anand K.

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Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer (vol 39, 110641, 2022)

CELL REPORTS

IF6.9

2022-04-01

OAAI

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Tumor-on-chip modeling of organ-specific cancer and metastasis

ADVANCED DRUG DELIVERY REVIEWS

IF17.6

2021-08-01

OAAI

Del Piccolo, Nuala; Shirure, Venktesh S.; Bi, Ye; Goedegebuure, S. Peter; Gholami, Sepideh; Hughes, Christopher C. W.; Fields, Ryan C.; George, Steven C.

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Engineering Vascularized Organoid-on-a-Chip Models

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021

IF0

2021-07-13

OAAI

Shirure, Venktesh S.; Hughes, Christopher C. W.; George, Steven C.

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A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular networks

MICROSYSTEMS & NANOENGINEERING

IF9.9

2021-01-06

OAAI

Yue, Tao; Zhao, Da; Phan, Duc T. T.; Wang, Xiaolin; Park, Joshua Jonghyun; Biviji, Zayn; Hughes, Christopher C. W.; Lee, Abraham P.

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The vascular niche in next generation microphysiological systems (Aug, 10.1039/d1lc00530h, 2021)

LAB ON A CHIP

IF5.4

2021-01-01

OAAI

Ewald, Makena L.; Chen, Yu-Hsi; Lee, Abraham P.; Hughes, Christopher C. W.

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An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy

LAB ON A CHIP

IF5.4

2021-01-01

OAAI

Hachey, Stephanie J.; Movsesyan, Silva; Nguyen, Quy H.; Burton-Sojo, Giselle; Tankazyan, Ani; Wu, Jie; Hoang, Tuyen; Zhao, Da; Wang, Shuxiong; Hatch, Michaela M.; Celaya, Elizabeth; Gomez, Samantha; Chen, George T.; Davis, Ryan T.; Nee, Kevin; Pervolarakis, Nicholas; Lawson, Devon A.; Kessenbrock, Kai; Lee, Abraham P.; Lowengrub, John; Waterman, Marian L.; Hughes, Christopher C. W.

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Research Directions