David A. Young - Publications, H-index & Citations

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David A. Young

newcastle university

67H-index

415Paper Count

1.7WCitation Count

Published Papers 114

Publication Date

Elevated MMP9 Expression—A Potential In Vitro Biomarker for COMPopathies

International Journal of Molecular Sciences

IF4.9

2026-03-04

OAAI

Helen F. Dietmar; Ella P. Dennis; Francesca M. Johnson de Sousa Brito; Louise N. Reynard; David A. Young; Michael D. Briggs

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Machine learning based prioritisation of genes associated with osteoarthritis joint damage in animals

Osteoarthritis and Cartilage

IF9

2026-01-14

PREAI

Jamie Soul; David A Young

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Transcriptomic profiling confirms microRNA-140 is more functional in joint development than in disease

Osteoarthritis and Cartilage

IF9

2025-11-14

PREAI

Yao Hao; Hua Lin; Jamie Soul; Lynne M Overman; Steven N. Lisgo; Jonathan Coxhead; Katarzyna A Piróg; Ian M. Clark; Matt J. Barter; Louise N. Reynard; David A. Young

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Dynamic Compression Improves Chondrogenesis in the Tissue Engineered Model of Cartilage

BIOTECHNOLOGY AND BIOENGINEERING

IF3.6

2025-05-25

OAAI

Marc V. Farcasanu; Thais de las Heras Ruiz; Francesca M. Johnson de Sousa Brito; Jamie Soul; Jonathan Coxhead; Matthew J. German; David A. Young

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The microRNA-455 null mouse shows dysregulated bone turnover

JBMR PLUS

IF2.4

2025-01-12

OAAI

Niu, Lingzi; Swingler, Tracey E.; Suelzu, Caterina; Ersek, Adel; Orriss, Isabel R.; Barter, Matthew J.; Hayman, Dan J.; Young, David A.; Horwood, Nicole; Clark, Ian M.

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microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity

BONE

IF3.6

2025-01-01

OAAI

Hayman, Dan J.; Brito, Francesca M. Johnson de Sousa; Lin, Hua; Prior, Amanda; Charlesworth, Gemma; Hao, Yao; Pearson, Rachel D.; Soul, Jamie; Clark, Ian M.; Pirog, Katarzyna A.; Barter, Matt J.; van't Hof, Rob J.; Young, David A.

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The methylomic landscape of human articular cartilage development contains epigenetic signatures of osteoarthritis risk

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2024-12-01

OAAI

Mcdonnell, Euan; Orr, Sarah E.; Barter, Matthew J.; Rux, Danielle; Brumwell, Abby; Wrobel, Nicola; Murphy, Lee; Overman, Lynne M.; Sorial, Antony K.; Young, David A.; Soul, Jamie; Rice, Sarah J.

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Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis models

DISEASE MODELS & MECHANISMS

IF3.3

2024-10-21

OAAI

Gilbert, Sophie J.; Soul, Jamie; Hao, Yao; Lin, Hua; Pirog, Katarzyna A.; Coxhead, Jonathan; Patel, Krutik; Barter, Matt J.; Young, David A.; Blain, Emma J.

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Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis

ELIFE

IF0

2024-10-14

OAAI

Patel, Krutik; Barter, Matt; Soul, Jamie; Clark, Peter; Proctor, Carole; Clark, Ian; Young, David; Shanley, Daryl P.

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DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation

BIOLOGICAL RESEARCH

IF4.6

2023-03-08

OAAI

Gomez, Rodolfo; Barter, Matt J.; Alonso-Perez, Ana; Skelton, Andrew J.; Proctor, Carole; Herrero-Beaumont, Gabriel; Young, David A.

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HDAC6 regulates NF-κB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression

SCIENTIFIC REPORTS

IF3.9

2022-04-22

OAAI

Barter, Matt J.; Butcher, Andrew; Wang, Hui; Tsompani, Dimitra; Galler, Martin; Rumsby, Ellen L.; Culley, Kirsty L.; Clark, Ian M.; Young, David A.

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Highly efficient CRISPR-Cas9-mediated editing identifies novel mechanosensitive microRNA-140 targets in primary human articular chondrocytes

OSTEOARTHRITIS AND CARTILAGE

IF9

2022-04-01

OAAI

Chaudhry, N.; Muhammad, H.; Seidl, C.; Downes, D.; Young, D. A.; Hao, Y.; Zhu, L.; Vincent, T. L.

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Osteoarthritis year in review: genetics, genomics, epigenetics

OSTEOARTHRITIS AND CARTILAGE

IF9

2022-02-01

OAAI

Young, D. A.; Barter, M. J.; Soul, J.

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Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association

BONE

IF3.6

2021-11-01

PREAI

Jones, Tania L.; Esa, Mohammed S.; Li, K. H. Christien; Krishnan, S. R. Gokul; Elgallab, George M.; Pearce, Mark S.; Young, David A.; Birrell, Fraser N.

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Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis

FEBS JOURNAL

IF4.2

2021-07-30

OAAI

Wilkinson, David J.; Falconer, Adrian M. D.; Wright, Helen L.; Lin, Hua; Yamamoto, Kazuhiro; Cheung, Kathleen; Charlton, Sarah H.; Arques, Maria del Carmen; Janciauskiene, Sabina; Refaie, Ramsay; Rankin, Kenneth S.; Young, David A.; Rowan, Andrew D.

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Increased hippocampal excitability in miR-324-null mice

SCIENTIFIC REPORTS

IF3.9

2021-05-17

OAAI

Hayman, Dan J.; Modebadze, Tamara; Charlton, Sarah; Cheung, Kat; Soul, Jamie; Lin, Hua; Hao, Yao; Miles, Colin G.; Tsompani, Dimitra; Jackson, Robert M.; Briggs, Michael D.; Pirog, Katarzyna A.; Clark, Ian M.; Barter, Matt J.; Clowry, Gavin J.; LeBeau, Fiona E. N.; Young, David A.

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The role of microRNA-3085 in chondrocyte function

SCIENTIFIC REPORTS

IF3.9

2020-12-14

OAAI

Le, Linh; Niu, Lingzi; Barter, Matthew J.; Young, David A.; Dalmay, Tamas; Clark, Ian M.; Swingler, Tracey E.

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microRNA-seq of cartilage reveals an overabundance of miR-140-3p which contains functional isomiRs

RNA

IF5

2020-07-13

OAAI

Woods, Steven; Charlton, Sarah; Cheung, Kat; Hao, Yao; Soul, Jamie; Reynard, Louise N.; Crowe, Natalie; Swingler, Tracey E.; Skelton, Andrew J.; Pirog, Katarzyna A.; Miles, Colin G.; Tsompani, Dimitra; Jackson, Robert M.; Dalmay, Tamas; Clark, Ian M.; Barter, Matt J.; Young, David A.

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Interplay between genetics and epigenetics in osteoarthritis

NATURE REVIEWS RHEUMATOLOGY

IF32.7

2020-04-09

100

PREAI

Rice, Sarah J.; Beier, Frank; Young, David A.; Loughlin, John

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CRELD2Is a NovelLRP1Chaperone That Regulates NoncanonicalWNTSignaling in Skeletal Development

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2020-03-17

OAAI

Dennis, Ella P.; Edwards, Sarah M.; Jackson, Robert M.; Hartley, Claire L.; Tsompani, Dimitra; Capulli, Mattia; Teti, Anna; Boot-Handford, Raymond P.; Young, David A.; Pirog, Katarzyna A.; Briggs, Michael D.

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Research Directions