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SaveShare Save Share Save Share Save Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target
Xing, Lixiao; Liu, Zhimin; Wang, Xinling; Liu, Qianying; Xu, Wei; Mao, Qiyu; Zhang, Xiang; Hao, Aihua; Xia, Shuai; Liu, Zezhong; Sun, Lujia; Zhang, Guangxu; Wang, Qian; Chen, Zhenguo; Jiang, Shibo; Sun, Lei Share Save Share Save Share Save An HR2-Mimicking Sulfonyl-γ-AApeptide Is a Potent Pan-coronavirus Fusion Inhibitor with Strong Blood-Brain Barrier Permeability, Long Half-Life, and Promising Oral BioavailabilityXue, Songyi; Xu, Wei; Wang, Lei; Wang, Xinling; Duan, Qianyu; Calcul, Laurent; Wang, Shaohui; Liu, Wenqi; Sun, Xingmin; Lu, Lu; Jiang, Shibo; Cai, Jianfeng Share Save A pan-sarbecovirus vaccine based on RBD of SARS-CoV-2 original strain elicits potent neutralizing antibodies against XBB in non-human primatesLiu, Zezhong; Zhou, Jie; Wang, Xinling; Xu, Wei; Teng, Zheng; Chen, Hongyou; Chen, Min; Zhang, Guangxu; Wang, Yuanzhou; Huang, Jinghe; Wang, Qian; Jiang, Shibo; Lu, Lu Share Save A novel cyclic γ-AApeptide-based long-acting pan-coronavirus fusion inhibitor with potential oral bioavailability by targeting two sites in spike proteinXue, Songyi; Wang, Xinling; Wang, Lei; Xu, Wei; Xia, Shuai; Sun, Lujia; Wang, Shaohui; Shen, Ning; Yang, Ziqi; Huang, Bo; Li, Sihao; Cao, Chuanhai; Calcul, Laurent; Sun, Xingmin; Lu, Lu; Cai, Jianfeng; Jiang, Shibo Share Save A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPsLiu, Zezhong; Zhou, Jie; Xu, Wei; Deng, Wei; Wang, Yanqun; Wang, Meiyu; Wang, Qian; Hsieh, Ming; Dong, Jingming; Wang, Xinling; Huang, Weijin; Xing, Lixiao; He, Miaoling; Tao, Chunlin; Xie, Youhua; Zhang, Yilong; Wang, Youchun; Zhao, Jincun; Yuan, Zhenghong; Qin, Chuan; Jiang, Shibo; Lu, Lu Share Save Share Save Engineered trimeric ACE2 binds viral spike protein and locks it in Three-up conformation to potently inhibit SARS-CoV-2 infectionGuo, Liang; Bi, Wenwen; Wang, Xinling; Xu, Wei; Yan, Renhong; Zhang, Yuanyuan; Zhao, Kai; Li, Yaning; Zhang, Mingfeng; Cai, Xia; Jiang, Shibo; Xie, Youhua; Zhou, Qiang; Lu, Lu; Dang, Bobo Share Save Share Save Share Save 
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